| ó㳺íà íàñåëåíèõ ì³ñöü | ISSN: 2707-0441 eISSN: 2707-045X |
Âèïóñê 75, 2025 - Ñòîð³íêè: 11-16
ÎÖ²ÍÊÀ ÏÎÄÐÀÇÍÞÞ×ÈÕ ÂËÀÑÒÈÂÎÑÒÅÉ ² ÎÁÃÐÓÍÒÓÂÀÍÍß ÃÐÀÍÈ×ÍÎ ÄÎÏÓÑÒÈÌί ÊÎÍÖÅÍÒÐÀÖ²¯ ÍÀÒÐ²Þ ÏÅÐÊÀÐÁÎÍÀÒÓ Ó ÏβÒв ÐÎÁÎ×ί ÇÎÍÈ
Êóçüì³íîâ Á.Ï.1, Çàçóëÿê Ò.Ñ.1, Êóçüì³íîâ Î.Á.1, Ëóêàñåâè÷ Í.Ô.1
1 Äåðæàâíå íåêîìåðö³éíå ï³äïðèºìñòâî «Ëüâ³âñüêèé íàö³îíàëüíèé ìåäè÷íèé óí³âåðñèòåò ³ìåí³ Äàíèëà Ãàëèöüêîãî»
ÓÄÊ: 614.71:[661.493:546.33]:615.099-047.44
ÀÍÎÒÀÖ²ß:
Ìåòà. Îö³íêà ïîäðàçíþþ÷èõ âëàñòèâîñòåé ³ îá´ðóíòóâàííÿ ãðàíè÷íî äîïóñòèìî¿ êîíöåíòðàö³¿ íàòð³þ ïåðêàðáîíàòó ó ïîâ³òð³ ðîáî÷î¿ çîíè.
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ. Íàòð³þ ïåðêàðáîíàò. Ìåòîäè äîñë³äæåíü – òîêñèêîëîãî-ã³ã³ºí³÷í³, ãåìàòîëîã³÷í³, á³îõ³ì³÷í³, ñòàòèñòè÷í³.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Ïðåäñòàâëåí³ ðåçóëüòàòè îö³íêè ïîäðàçíþþ÷èõ âëàñòèâîñòåé íàòð³þ ïåðêàðáîíàòó, ÿêèé øèðîêî çàñòîñîâóºòüñÿ ÿê åêîëîã³÷íèé êèñíåâèé â³äá³ëþâà÷, ïëÿìîâèâ³äíèê, äåç³íôåêòîð òà î÷èñíèê â ïîáóò³, ïðîìèñëîâîñò³ (òåêñòèëüí³é, õ³ì³÷í³é, êîñìåòè÷í³é) ìåäèöèí³ òà ñ³ëüñüêîìó ãîñïîäàðñòâ³. Ðîáîòà áóëà ïðîâåäåíà íà á³ëèõ ùóðàõ-ñàìêàõ, ÿêèì ³íòðàíàçàëüíî ââîäèëè íàòð³þ ïåðêàðáîíàò â äîçàõ, ùî â³äïîâ³äàëè â ïåðåðàõóíêó íà êîíöåíòðàö³¿ 90 ìã/ì3, 30 ìã/ì3 òà 10 ìã/ì3. Âèçíà÷åííÿ ãåìàòîëîã³÷íèõ ³ á³îõ³ì³÷íèõ ïîêàçíèê³â, ïîâåä³íêîâèõ ðåàêö³é ³ êë³òèííîãî ñêëàäó áðîíõîàëüâåîëÿðíîãî ëàâàæó ïðîâîäèëè íà ïåðøó òà òðåòþ äîáó ï³ñëÿ ââåäåííÿ. Âñòàíîâëåíî, ùî ïîð³ã îäíîêðàòíî¿ ³íãàëÿö³éíî¿ ä³¿ çà çàãàëüíîòîêñè÷íèì åôåêòîì ñêëàäຠ90 ìã/ì3, ïðî ùî ñâ³ä÷àòü çì³íè ãåìàòîëîã³÷íèõ ïîêàçíèê³â òà ïîâåä³íêîâèõ ðåàêö³é òâàðèí ïðè ³íòðàíàçàëüíîìó ââåäåíí³ íàòð³þ ïåðêàðáîíàòó. Êîíöåíòðàö³þ 30 ìã/ì3 ìîæíà ââàæàòè ïîðîãîì ïîäðàçíþþ÷î¿ ä³¿, îñê³ëüêè âïëèâ íàòð³þ ïåðêàðáîíàòó íà öüîìó ð³âí³ âèêëèêàâ çíà÷èì³ çì³íè ó ñï³ââ³äíîøåíí³ êë³òèííèõ åëåìåíò³â áðîíõîàëüâåîëÿðíîãî ëàâàæó òà âàãîâîãî êîåô³ö³ºíòó ëåãåíü. Íàòð³þ ïåðêàðáîíàò âèêëèêຠïîðóøåííÿ ôóíêö³îíàëüíîãî ñòàíó äèõàëüíî¿ ñèñòåìè ó êîíöåíòðàö³¿, ÿê³ çíàõîäÿòüñÿ íèæ÷å ïîðîãó ³íãàëÿö³éíî¿ ä³¿ çà çàãàëüíîòîêñè÷íèì åôåêòîì ³ â³äíîñèòüñÿ äî ðå÷îâèí ç³ ñïåöèô³÷íîþ ïîäðàçíþþ÷îþ 䳺þ. Ç âðàõóâàííÿì ïîðîãó òà çîíè ïîäðàçíþþ÷î¿ ä³¿ íàòð³þ ïåðêàðáîíàòó ðîçðàõîâàíî ãðàíè÷íî äîïóñòèìó êîíöåíòðàö³þ ó ïîâ³òð³ ðîáî÷î¿ çîíè.
Âèñíîâêè. Íàòð³þ ïåðêàðáîíàò â³äíîñèòüñÿ äî ðå÷îâèí ç³ ñïåöèô³÷íîþ ïîäðàçíþþ÷îþ 䳺þ.
Ãðàíè÷íî äîïóñòèìà êîíöåíòðàö³ÿ íàòð³þ ïåðêàðáîíàòó ó ïîâ³òð³ ðîáî÷î¿ çîíè ðåêîìåíäóºòüñÿ íà ð³âí³ 2 ìã/ì3, àåðîçîëü, 3 êëàñ íåáåçïå÷íîñò³, ïîçíà÷êà Ï – ïîäðàçíþþ÷à ä³ÿ.
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ. Íàòð³þ ïåðêàðáîíàò. Ìåòîäè äîñë³äæåíü – òîêñèêîëîãî-ã³ã³ºí³÷í³, ãåìàòîëîã³÷í³, á³îõ³ì³÷í³, ñòàòèñòè÷í³.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Ïðåäñòàâëåí³ ðåçóëüòàòè îö³íêè ïîäðàçíþþ÷èõ âëàñòèâîñòåé íàòð³þ ïåðêàðáîíàòó, ÿêèé øèðîêî çàñòîñîâóºòüñÿ ÿê åêîëîã³÷íèé êèñíåâèé â³äá³ëþâà÷, ïëÿìîâèâ³äíèê, äåç³íôåêòîð òà î÷èñíèê â ïîáóò³, ïðîìèñëîâîñò³ (òåêñòèëüí³é, õ³ì³÷í³é, êîñìåòè÷í³é) ìåäèöèí³ òà ñ³ëüñüêîìó ãîñïîäàðñòâ³. Ðîáîòà áóëà ïðîâåäåíà íà á³ëèõ ùóðàõ-ñàìêàõ, ÿêèì ³íòðàíàçàëüíî ââîäèëè íàòð³þ ïåðêàðáîíàò â äîçàõ, ùî â³äïîâ³äàëè â ïåðåðàõóíêó íà êîíöåíòðàö³¿ 90 ìã/ì3, 30 ìã/ì3 òà 10 ìã/ì3. Âèçíà÷åííÿ ãåìàòîëîã³÷íèõ ³ á³îõ³ì³÷íèõ ïîêàçíèê³â, ïîâåä³íêîâèõ ðåàêö³é ³ êë³òèííîãî ñêëàäó áðîíõîàëüâåîëÿðíîãî ëàâàæó ïðîâîäèëè íà ïåðøó òà òðåòþ äîáó ï³ñëÿ ââåäåííÿ. Âñòàíîâëåíî, ùî ïîð³ã îäíîêðàòíî¿ ³íãàëÿö³éíî¿ ä³¿ çà çàãàëüíîòîêñè÷íèì åôåêòîì ñêëàäຠ90 ìã/ì3, ïðî ùî ñâ³ä÷àòü çì³íè ãåìàòîëîã³÷íèõ ïîêàçíèê³â òà ïîâåä³íêîâèõ ðåàêö³é òâàðèí ïðè ³íòðàíàçàëüíîìó ââåäåíí³ íàòð³þ ïåðêàðáîíàòó. Êîíöåíòðàö³þ 30 ìã/ì3 ìîæíà ââàæàòè ïîðîãîì ïîäðàçíþþ÷î¿ ä³¿, îñê³ëüêè âïëèâ íàòð³þ ïåðêàðáîíàòó íà öüîìó ð³âí³ âèêëèêàâ çíà÷èì³ çì³íè ó ñï³ââ³äíîøåíí³ êë³òèííèõ åëåìåíò³â áðîíõîàëüâåîëÿðíîãî ëàâàæó òà âàãîâîãî êîåô³ö³ºíòó ëåãåíü. Íàòð³þ ïåðêàðáîíàò âèêëèêຠïîðóøåííÿ ôóíêö³îíàëüíîãî ñòàíó äèõàëüíî¿ ñèñòåìè ó êîíöåíòðàö³¿, ÿê³ çíàõîäÿòüñÿ íèæ÷å ïîðîãó ³íãàëÿö³éíî¿ ä³¿ çà çàãàëüíîòîêñè÷íèì åôåêòîì ³ â³äíîñèòüñÿ äî ðå÷îâèí ç³ ñïåöèô³÷íîþ ïîäðàçíþþ÷îþ 䳺þ. Ç âðàõóâàííÿì ïîðîãó òà çîíè ïîäðàçíþþ÷î¿ ä³¿ íàòð³þ ïåðêàðáîíàòó ðîçðàõîâàíî ãðàíè÷íî äîïóñòèìó êîíöåíòðàö³þ ó ïîâ³òð³ ðîáî÷î¿ çîíè.
Âèñíîâêè. Íàòð³þ ïåðêàðáîíàò â³äíîñèòüñÿ äî ðå÷îâèí ç³ ñïåöèô³÷íîþ ïîäðàçíþþ÷îþ 䳺þ.
Ãðàíè÷íî äîïóñòèìà êîíöåíòðàö³ÿ íàòð³þ ïåðêàðáîíàòó ó ïîâ³òð³ ðîáî÷î¿ çîíè ðåêîìåíäóºòüñÿ íà ð³âí³ 2 ìã/ì3, àåðîçîëü, 3 êëàñ íåáåçïå÷íîñò³, ïîçíà÷êà Ï – ïîäðàçíþþ÷à ä³ÿ.
ÊËÞ×β ÑËÎÂÀ:
Íàòð³þ ïåðêàðáîíàò, ïîäðàçíþþ÷³ âëàñòèâîñò³, ãðàíè÷íî äîïóñòèìà êîíöåíòðàö³ÿ, ïîâ³òðÿ ðîáî÷î¿ çîíè.
˲ÒÅÐÀÒÓÐÀ:
1. Sodium percarbonate and its applications. Available from: https://www.distripark.eu/en/blog/sodium-percarbonate-and-its-applications
2. Sodium percarbonate CAS N°: 15630-89-4. Available from: https://hpvchemicals.oecd.org/UI/handler.axd?id=5681c280-6686-4260-b629-2f23a6db2319
3. Momma J, Takada K, Suzuki Y, Tobe M. Acute Oral Toxicity and Ocular Irritation of Chemicals in Bleaching Agents. Shokuhin Eiseigaku Zasshi. 1986;27(5):553-60. doi: https://doi.org/10.3358/shokueishi.27.553
4. [Methodological guidelines for conducting research on the study of irritating properties and substantiation of maximum permissible concentrations of selectively acting irritating substances in the air of the working area (approved by the Deputy Chief State Sanitary Doctor of the USSR on August 11, 1980, No. 2196-80)]. Ukrainian.
5. European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes: European Communities (EC). European Treaty Series No. 123. Strasbourg; 1986. Available from: http://www.conventions.coe.int/treaty/en/treaties/html/123.htm
6. [On approval of the Procedure for conducting experiments on animals by scientific institutions. Order of the Ministry of Education, Science, Youth and Sports of Ukraine dated 01.03.2012 No. 249]. Official Gazette of Ukraine. 2012;24. 82 p. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/z0416-12#Text