Ìåòà. Äîñë³äèòè äèíàì³êó çì³í ïîêàçíèê³â ïåðåêèñíîãî îêèñíåííÿ ë³ï³ä³â òà àíòèîêñèäàíòíîãî çàõèñòó â êðîâ³ é òêàíèí³ ïå÷³íêè çà óìîâ âïëèâó ñâèíöþ äî òà ï³ä ÷àñ ïðîâåäåííÿ á³îëîã³÷íî¿ êîðåêö³¿.
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ. Åêñïåðèìåíòàëüí³ äîñë³äæåííÿ ïðîâîäèëè íà á³ëèõ ùóðàõ-ñàìöÿõ ìàñîþ ò³ëà 170-200 ã óïðîäîâæ 30 ä³á. Òâàðèíè ðîçïîä³ëåí³ íà äâ³ ãðóïè։ ïåðøà ãðóïà îòðèìóâàëà Pb(NO3)2, äðóãà ãðóïà Pb(NO3)2 ³ á³îïðîòåêòîðè. Âîäí³ ðîç÷èíè ïëþìáóìó í³òðàòó (ñâèíåöü) óâîäèëè íàòùå ó øëóíîê ó äîç³ 36 ìã/êã ìàñè ò³ëà. ßê á³îëîã³÷í³ ïðîòåêòîðè íåãàòèâíîãî âïëèâó ñâèíöþ çàñòîñîâóâàëè ïåêòèí, êàëüö³é òà àíòèîêñèäàíòè – â³òàì³íè Ñ, Å, β-êàðîòèí ³ ñåëåí (êàïñóëà ïðåïàðàòó òð³îâ³òó). Òâàðèíàì êîíòðîëüíèõ ãðóï óâîäèëè ïèòíó âîäó, à òàêîæ äîäàâàëè äî ðàö³îíó â³äïîâ³äí³ îáðàí³ á³îïðîòåêòîðè. Ó êðîâ³ òà òêàíèí³ ïå÷³íêè âèçíà÷àëè âì³ñò 䳺íîâèõ êîí’þãàò³â, ìàëîíîâîãî ä³àëüäåã³äó, àêòèâí³ñòü ñóïåðîêñèääèñìóòàçè, àêòèâí³ñòü êàòàëàçè, ³íäåêñ àíòèîêñèäàíòî¿ àêòèâíîñò³. Çà ñï³ââ³äíîøåííÿìè ïîêàçíèê³â àêòèâíîñò³ àíòèîêñèäàíòíîãî çàõèñòó òà ³íòåíñèâíîñò³ ïðîöåñ³â ë³ïîïåðîêñèäàö³¿ ðîçðàõîâóâàëè ³íòåãðàëüíèé êîåô³ö³ºíò, ùî õàðàêòåðèçóº àíòèîêñèäàíòíèé ñòàí îðãàí³çìó.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Âèÿâëåíî, ùî óïðîäîâæ äîñë³äó ð³âåíü ïðîäóêò³â ïåðåêèñíîãî îêèñíåííÿ ë³ï³ä³â áóâ ï³äâèùåíèé: 䳺íîâèõ êîí'þãàò³â ó êðîâ³ íà 70,8% – 114,8%, ó ïå÷³íö³ – íà 27,3% – 94,6%, ìàëîíîâîãî ä³àëüäåã³äó íà 28,3% – 97,6% ³ 24,5% – 91,5% â³äïîâ³äíî ïðîòè êîíòðîëþ. Îäíî÷àñíî íà 15 äîáó äîñë³äó ï³äâèùèëàñÿ àêòèâí³ñòü ñóïåðîêñèääèñìóòàçè – íà 34,2% ó êðîâ³, ó òêàíèí³ ïå÷³íêè àêòèâí³ñòü ôåðìåíòó ïðàêòè÷íî íå çì³íèëàñÿ, àêòèâí³ñòü êàòàëàçè çíèçèëàñÿ. Íàïðèê³íö³ äîñë³äó àêòèâí³ñòü ôåðåìåíò³â ñóïåðîêñèääèñìóòàçè ³ êàòàëàçè çìåíøèëàñÿ, á³ëüøîþ ì³ðîþ ó êðîâ³, í³æ ó òêàíèí³ ïå÷³íêè. Îòðèìàí³ ðåçóëüòàòè ñâ³ä÷àòü ïðî çðîñòàííÿ îêñèäàòèâíîãî ñòðåñó â äèíàì³ö³ ³íòîêñèêàö³¿ ñâèíöåì, ùî ï³äòâåðäæóºòüñÿ íèçüêèìè çíà÷åííÿìè ³íòåãðàëüíèõ êîåô³ö³ºíò³â. Äîäàâàííÿ äî ðàö³îíó êîìïëåêñó á³îïðîòåêòîð³â óïðîäîâæ óñüîãî äîñë³äó çà îäíî÷àñíîãî íàäõîäæåííÿ ñâèíöþ íàëàãîäæóº ð³âíîâàãó â ñèñòåì³ ïåðåêèñíå îêèñíåííÿ ë³ï³ä³â – àíòèîêñèäàíòíèé çàõèñò òêàíèíè ïå÷³íêè òà êðîâ³.
Âèñíîâêè. Ïëþìáóìó í³òðàò ñïðè÷èíèâ îêñèäàòèâíèé ñòðåñ ó ï³ääîñë³äíèõ òâàðèí. Êîìïëåêñ á³îïðîòåêòîð³â – ïåêòèíó, êàëüö³þ, â³òàì³í³â Ñ ³ Å, β-êàðîòèíó ³ ñåëåíó àêòèâóº ìåòàáîë³÷í³ ïðîöåñè òà îïòèìàëüíî êîðèãóº ïîðóøåííÿ ñï³ââ³äíîøåííÿ àêòèâíîñò³ ïðîöåñ³â ó ïðî- òà àíòèîêñèäàíòí³é ñèñòåì³, âèêëèêàíèõ 䳺þ ñâèíöþ.

Ïëþìáóìó í³òðàò, êðîâ, òêàíèíà ïå÷³íêè, 䳺íîâ³ êîí'þãàòè, ìàëîíîâèé ä³àëüäåã³ä, ñóïåðîêñèääèñìóòàçà, êàòàëàçà, á³îïðîòåêòîðè.

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Ôåäîðåíêî Þ.Â. Ïðîöåñè ïåðåêèñíîãî îêèñíåííÿ ë³ï³ä³â ³ àíòèîêñèäàíòíîãî çàõèñòó ó êðîâ³ òà ïå÷³íö³ çà óìîâ âïëèâó ñâèíöþ ³ ¿õ êîðåêö³ÿ â åêñïåðèìåíòàëüíèõ äîñë³äæåííÿõ. ó㳺íà íàñåëåíèõ ì³ñöü : çá. íàóê. ïð. Ê., 2023. Âèï. 73. Ñ. 59-67.