Ìåòà. Âñòàíîâëåííÿ ïàðàìåòð³â òîêñè÷íîñò³ òà îáãðóíòóâàííÿ ãðàíè÷íî äîïóñòèìî¿ êîíöåíòðàö³¿ ãåðá³öèäó êëîï³ðàë³äó â ïîâ³òð³ ðîáî÷î¿ çîíè.
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ. Êëîï³ðàë³ä (3,6-äèõëîðï³ðèäèí-2-êàðáîíîâà êèñëîòà) âèðîáíèöòâà ô³ðìè SUPERUS Co. Ltd (Êèòàé). Ìåòîäè äîñë³äæåíü – òîêñèêîëîãî-ã³ã³ºí³÷í³, á³îõ³ì³÷í³, ³ìóíîëîã³÷í³, ô³çèêî-õ³ì³÷í³, ñòàòèñòè÷í³.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Ïðåäñòàâëåí³ ðåçóëüòàòè òîêñèêîëîãî-ã³ã³ºí³÷íèõ äîñë³äæåíü ãåðá³öèäó êëîï³ðàë³äó íà ëàáîðàòîðíèõ òâàðèíàõ (á³ë³ ìèø³, á³ë³ ùóð³, ìóð÷àêè, êðîë³). Âñòàíîâëåíî, ùî êëîï³ðàë³ä çà ïàðàìåòðàìè ãîñòðî¿ òîêñè÷íîñò³ ïðè îäíîðàçîâîìó âíóòð³øíüîøëóíêîâîìó ââåäåíí³ òà îäíîêðàòíîìó íàíåñåíí³ íà øê³ðó â³äíîñèòüñÿ äî ìàëîíåáåçïå÷íèõ ðå÷îâèí (4 êëàñ íåáåçïå÷íîñò³), ïðè îäíîêðàòíîìó ³íãàëÿö³éíîìó âïëèâ³ - äî ïîì³ðíî íåáåçïå÷íèõ ðå÷îâèí (3 êëàñ íåáåçïå÷íîñò³), íå âîëî䳺 øê³ðíî-ðåçîðáòèâíîþ 䳺þ, ïðîÿâëÿº ñåðåäíüî âèðàæåíèé ïîäðàçíþâàëüíèé åôåêò ïðè áàãàòîðàçîâîìó ïîïàäàíí³ íà øê³ðó òà ñèëüíî âèðàæåíèé ïîäðàçíþâàëüíèé åôåêò ïðè ïîïàäàíí³ íà ñëèçîâ³ îáîëîíêè, âèêëèêຠñåíñèá³ë³çàö³þ îðãàí³çìó. Ïðè ñóáõðîí³÷íîìó ïåðîðàëüíîìó âïëèâ³ òà áàãàòîðàçîâîìó íàíåñåíí³ íà øê³ðó ïðîÿâëÿº ñëàáê³ êóìóëÿòèâí³ âëàñòèâîñò³. Ãîíàäîòîêñè÷íèé, åìáð³îòîêñè÷íèé òà òåðàòîãåííèé åôåêòè îáóìîâëåí³ çàãàëüíîòîêñè÷íîþ 䳺þ êëîï³ðàë³äó. Ãåíîòîêñè÷íèõ òà êàíöåðîãåííèõ âëàñòèâîñòåé íå âèÿâëåíî. Íà ï³äñòàâ³ âñòàíîâëåíèõ ïàðàìåòð³â òîêñè÷íîñò³ ðîçðàõîâàíî êîåô³ö³ºíò çàïàñó, çàïðîïîíîâàíî ãðàíè÷íî äîïóñòèìó êîíöåíòðàö³þ êëîï³ðàë³äó ó ïîâ³òð³ ðîáî÷î¿ çîíè òà ðîçðîáëåíî ìåòîäèêó âèì³ðþâàííÿ ìàñîâî¿ êîíöåíòðàö³¿ ïðåïàðàòó.
Âèñíîâêè. Ãðàíè÷íî äîïóñòèìà êîíöåíòðàö³ÿ êëîï³ðàë³äó ó ïîâ³òð³ ðîáî÷î¿ çîíè ðåêîìåíäóºòüñÿ íà ð³âí³ 1,0 ìã/ì3, àåðîçîëü, 2 êëàñ íåáåçïå÷íîñò³, ïîçíà÷êà + - ïîòðåáóº ñïåö³àëüíîãî çàõèñòó î÷åé. Ðîçðîáëåíî ãàçîõðîìàòîãðàô³÷íó ìåòîäèêó âèì³ðþâàííÿ ìàñîâî¿ êîíöåíòðàö³¿ êëîï³ðàë³äó ó ïîâ³òð³.

Êëîï³ðàë³ä, ïàðàìåòðè òîêñè÷íîñò³, ãðàíè÷íî äîïóñòèìà êîíöåíòðàö³ÿ, ïîâ³òðÿ ðîáî÷î¿ çîíè.

1. Clopyralid. Available from: https://superagronom.com/substance/klopiralid-id17679

2. PubChem. Clopyralid. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Clopyralid#section=Odor

3. European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes: European Communities (EC) – Strasbourg, 18.III.1986. European Treaty Series No. 123. Available from: http://www.conventions.coe.int/treaty/en/treaties/html/123.htm

4. [The procedure for research and experiments on animals by scientific institutions: Order of the Ministry of Education, Science, Youth and Sports of Ukraine dated March 1, 2012 No. 249.] Ofitsiinyi Visnyk Ukrainy. 2012.24:82. Ukrainian.

5. [State medical and sanitary standards for the permissible content of chemical substances in the air of the working area (approved by the order of the Ministry of Health dated 07/09/2024 No. 1192, registered in the Ministry of Justice on 08/24/2024 under No. 1107/42452)]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/z1107-24#Text

6. California Environmental Protection Agency/Department of Pesticide Regulation; Toxicology Data Review Summaries on Clopyralid (1702-17-6).

7. [Methodical notes “Investigation of the immunotoxic action of potentially unsafe chemical substances under their hygienic regulation” (approved by order of the Ministry of Health dated July 25, 2003 No. 356)]. Available from: https://zakononline.com.ua/documents/show/63930___63930

8. Shysh NV. [Damaging effect of long-term administration of clopyralid on the reproductive system of male rats]. Bulletin of the Ukrainian Medical Dental Academy. 2006;6(3):19-22. Russian.

9. Hayes WC, Smith FA, John JA, Rao KS. Teratologic evaluation of 3,6-Dichloropicolinic acid in rats and rabbits. Fundam Appl Toxicol.1984;4(1):91-7. doi: https://doi.org/10.1016/0272-0590(84)90222-7

10. [Guidelines for establishing indicative safe levels of exposure to harmful substances in the air of the working area No. 4000–85]. Moscow, 1985. Russian.

Êóçüì³íîâ Á.Ï., Çàçóëÿê Ò.Ñ., Êóçüì³íîâ Î.Á., Ëóêàñåâè÷ Í.Ô., ×åìîäóðîâà Í.ª. Îö³íêà íåáåçïå÷íîñò³ òà îá´ðóíòóâàííÿ ìåäèêî-ñàí³òàðíîãî íîðìàòèâó êëîï³ðàë³äó â ïîâ³òð³ ðîáî÷î¿ çîíè. ó㳺íà íàñåëåíèõ ì³ñöü : çá. íàóê. ïð. Ê., 2024. Âèï. 74. Ñ. 68-74.