Ìåòà: äîñë³äæåííÿ îñîáëèâîñòåé ðåàêö³é åðèòðîöèòàðíî¿ ñèñòåìè êðîâ³ òà îö³íêà ìîæëèâîñò³ ¿õ âèêîðèñòàííÿ äëÿ âèÿâëåííÿ ôóíêö³îíàëüíèõ çñóâ³â â îðãàí³çì³ òâàðèí ï³ä âïëèâîì õëîðîôîðìó òà ñóëüôàòó àëþì³í³þ.
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ: êîìá³íîâàíà ä³ÿ õëîðîôîðìó òà ñóëüôàòó àëþì³í³þ íà åðèòðîöèòàðí³ ïîêàçíèêè.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Òåíäåíö³ÿ äî çíèæåííÿ ð³âíÿ ãåìîãëîá³-íó, çíèæåííÿ âì³ñòó ãåìîãëîá³íó â îäíîìó åðèòðîöèò³ òà çíèæåííÿ àáñîëþòíî¿ ê³ëüêîñò³ åðèòðîöèò³â ìîæå ñâ³ä÷èòè ïðî ïåðåáóäîâó â åðèòðîöèòàðí³é ñèñòåì³ êðîâ³. Âèÿâëåí³ çì³íè ìîæóòü âêàçóâàòè íà ð³çí³ øâèäêîñò³ ñèíòåçó òà íàêîïè÷åííÿ ãåìîãëîá³íó â åðèòðîöèòàðíèõ êë³òèíàõ ê³ñòêîâîãî ìîçêó ï³ääîñë³äíèõ òà êîíòðîëüíèõ òâàðèí òà íà ôóíêö³îíàëüíó íåäîñòàòí³ñòü çð³ëèõ ôîðì åðèòðîöèò³â ó ï³ääîñë³äíèõ òâàðèí. Ôóíêö³îíàëüíà íåäîñòàòí³ñòü êèñíåâî-òðàíñïîðòíî¿ ôóíêö³¿ åðèòðîöèò³â ìîæå âèêëèêàòè â îðãàí³çì³ êèñíåâó íåäîñòàòí³ñòü, ç ïîäàëüøèì ðîçâèòêîì ïîðóøåíü ôóíêö³îíóâàííÿ âñ³õ îðãàí³â òà ñèñòåì îðãàí³çìó.
Âèñíîâêè. Ãåìàòîëîã³÷í³ äîñë³äæåííÿ âèÿâèëè ÿê³ñí³ òà ê³ëüê³ñí³ çì³íè åðèòðîöèòàðíèõ êë³òèí. Âñòàíîâëåíî, ùî õàðàêòåð ³ âèðàæåí³ñòü åôåêò³â çàëåæàëè â³ä ä³þ÷î¿ ðå÷îâèíè, ð³âí³â ¿õ ÃÄÊ (äîçà) òà ÷àñó ¿õ âïëèâó. Íàéâèðàçí³ø³ çì³íè ìîæíà ñïîñòåð³ãàòè â ãðóïàõ òâàðèí ç ìàêñèìàëüíèì ð³âíåì íàâàíòàæåííÿì – 3 òà 5 ÃÄÊ, ÿê ïðè ³çîëüîâàí³é 䳿 õëîðîôîðìó òà À1, òàê ³ çà óìîâ ¿õ ïîºäíàíî¿ ä³¿.

õëîðîôîðì, ñóëüôàò àëþì³í³þ, êîìá³íîâàíà ä³ÿ, åðèòðîöèòàðíà ñèñòåìà êðîâ³.

1. ßöèê À.Â. Âîäîãîñïîäàðñüêà åêîëîã³ÿ. Ê.: Ãåíåçà, 2004. Òîì 3. Ñ. 172-183.

2. Ïðîêîïîâ Â.Î. Ïèòíà âîäà Óêðà¿íè: ìåäèêî-åêîëîã³÷í³ òà ñàí³òàðíî-ã³ã³ºí³÷í³ àñïåêòè. Çà ðåä. À.Ì. Ñåðäþêà. Ê.: ÂÑ «Ìåäèöèíà». 2016. Ñ. 173-174, 190-196.

3. Ïðîêîïîâ Â.Î., ×è÷êîâñüêà Ã.Â., Çîð³íà Î.Â. Õëîðîðãàí³÷í³ ñïîëóêè ó ïèòí³é âîä³: ôàêòîðè òà óìîâè ¿õ óòâîðåííÿ. Äîâê³ëëÿ òà çäîðîâ'ÿ. 2004. ¹2 (29). Ñ. 70-73.

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6. Çàïîëüñüêèé À.Ê. ϳäãîòîâêà âèñîêîÿê³ñíî¿ âîäè â õàð÷îâ³é ïðîìèñëîâîñò³. ²V ̳æíàðî-äíèé Âîäíèé Ôîðóì «Àêâà-Óêðà¿íà 2006». ̳æíàðîäíèé Ôîðóì «Åêîëîã³÷í³ òåõíîëî㳿 – 2006». 2006. Ñ. 338-339.

7. ßðîøåíêî Ê.Ê., Øàáàíîâ Ì.Â. Åôåêòèâí³ñòü êîàãóëÿö³éíîãî î÷èùåííÿ âîäíèõ ñòîê³â êåðàì³÷íîãî âèðîáíèöòâà.. Çá³ðíèê íàóêîâèõ ïðàöü ²íñòèòóòó ãåîõ³ì³¿ íàâêîëèøíüîãî ñåðåäîâèùà. Ê.: ²ÃÍÑ, 2011. Âèï. 19. Ñ. 95-101.

8. Àíäðóñèøèíà ².Ì. Àëþì³í³é ó ïèòí³é âîä³ òà çäîðîâ’ÿ ëþäèíè. Êè¿â, 2018. 38 ñ.

9. Shtabskiy B.M., Hzhehotskiy M.R. Xenobiotics, chemical homeostasis and human security. Lviv, Nautilus, 1999. 308 p.

10. Effect of magnetic field and constantly industrial frequency lighting on blood rat. A.D. Belkin, S.V. Michurina, A.V. Shulgyna, S.A. Arkhipov et al. Hygiene and sanitation. 2005. ¹5. P. 37-40.

11. Principles and methods for assessing direct immunotoxicity associated with exposure to chemicals. Geneva: WHO, 1996. 390 ð.

12. Ëàáîðàòîðí³ òâàðèíè â ìåäèêî-á³îëîã³÷íèõ åêñïåðèìåíòàõ. Â.Ï. ϳøàê, Â.Ã. Âèñîöüêà, Â.Ì. Ìàãàëÿñ òà ³í. ×åðí³âö³: Ìåä óí³âåðñèòåò, 2006. 350 ñ.

13. Àíòîìîíîâ Ì.Þ. Ìàòåìàòè÷åñêàÿ îáðàáîòêà è àíàëèç ìåäèêî-áèîëîãè÷åñêèõ äàííûõ. Ê., 2018. 579 ñ.

Òîìàøåâñüêà Ë.À., Ïðîêîïîâ Â.Î., Êðàâ÷óí Ò.ª., Ëèïîâåöüêà Î.Á., ijäèê Í.Â. Äîñë³äæåííÿ ³çîëüîâàíî¿ òà êîìá³íîâàíî¿ ä³¿ õëîðîôîðìó òà ñóëüôàòó àëþì³í³þ ç ïèòíîþ âîäîþ íà åðèòðîöèòàðíó ñèñòåìó êðîâ³ òâàðèí. ó㳺íà íàñåëåíèõ ì³ñöü : çá. íàóê. ïð. Ê., 2021. Âèï. 71. Ñ. 111-117.