Ìåòà: äîñë³äèòè îñîáëèâîñò³ âçàºìîçâ’ÿçê³â ì³æ óëüòðàñòðóêòóðàìè åíåðãåòè÷íîãî íàïðÿìó ä³ÿëüíîñò³ ôîë³êóëÿðíèõ òèðîöèò³â ïðè ïðèéìàíí³ îðãàí³÷íîãî éîäó çà óìîâ ïîòåíö³þâàííÿ äåô³öèòó éîäó â ðàö³îí³ àíòèòèðåî¿äíèì çàñîáîì ìåðêàçîë³ë (Thiamazol).
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ. Îá’ºêòîì äîñë³äæåííÿ áóëè åëåêòðîíîãðàìè ùèòîïîä³áíèõ çàëîçàõ 40 á³ëèõ íåë³í³éíèõ ùóð³â-ñàìö³â ïî÷àòêîâî¿ ìàñè ò³ëà 140-160 ã, éîãî ïðåäìåòîì – çì³íè ìîðôîôóíêö³îíàëüíîãî ñòàíó óëüòðàñòðóêòóð ïðîô³ëþ åíåðãåòè÷íî¿ ìîæëèâîñò³ ôîë³êóëÿðíèõ òèðîöèò³â ïðè ïðèéìàíí³ ìàëî¿ (ì³í³ìàëüíî ä³þ÷î¿), ïîì³ðíî¿ òà âåëèêî¿ äîç îðãàí³÷íîãî éîäó çà óìîâ ìåäèêàìåíòîçíîãî ïîòåíö³þâàííÿ àë³ìåíòàðíîãî éîäîäåô³öèòó ìåðêàçîë³ëîì ó äîç³ 3 ìã/êã ìàñè ò³ëà. Ðîáîòó âèêîíàíî ìåòîäàìè åëåêòðîííî¿ ì³êðîñêîﳿ, íàï³âê³ëüê³ñíîãî àíàë³çó åëåêòðîíîãðàì, âèçíà÷åííÿ ïðîô³ë³â ñïåö³àëüíèõ ìîæëèâîñòåé ãîðìîíîïîåòè÷íèõ êë³òèí, êîðåëÿö³éíîãî àíàë³çó; ³íòåðïðåòàö³þ ðåçóëüòàò³â çä³éñíåíî ç ïîçèö³é öèòîô³ç³îëî㳿.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Óñòàíîâëåíî, ùî ïðè ïîòåíö³þâàíí³ àë³ìåíòàðíîãî éîäîäåô³öèòó åíåðãîçàáåçïå÷åííÿ òèðåî¿äíîãî ãîðìîíîïîåçó ïîðóøóºòüñÿ. Îñîáëèâîñò³ êîðèãóâàííÿ îðãàí³÷íèì éîäîì ðîçëàä³â åíåðãîçàáåçïå÷åííÿ ãîðìîíîïîåçó áóëè ïîâ’ÿçàí³ ç ôàêòîì ïðèéìàííÿ éîäó òà éîãî äîçîþ. Çðîñòàííÿ åíåðãåòè÷íîãî ïîòåíö³àëó ôîë³êóëÿðíèõ òèðîöèò³â ï³ä âïëèâîì îðãàí³÷íîãî éîäó ïîëÿãàëî â çá³ëüøåíí³ ê³ëüêîñò³ ì³òîõîíäð³é òà ðèáîñîì íà ¿õí³õ êðèñòàõ, ï³äâèùåíí³ åëåêòðîííî¿ ù³ëüíîñò³ ì³òîõîíäð³àëüíîãî ìàòðèêñó, â³äíîâëåíí³ òîïîãðàô³÷íîãî çâ’ÿçêó ì³æ îñíîâíèìè óëüòðàñòðóêòóðàìè, ùî çàáåçïå÷óþòü ñïåöèô³÷íó ä³ÿëüí³ñòü òèðîöèòó (ì³òîõîíäð³¿, ðåòèêóëÿðíèé åíäîïëàçìàòè÷íèé ðåòèêóëóì, êîìïëåêñ Ãîëüäæ³). Ïðèéìàííÿ íàâ³òü ìàëî¿ ê³ëüêîñò³ îðãàí³÷íîãî éîäó ñïðèÿëî çðîñòàííþ ïîòåíö³éíèõ ìîæëèâîñòåé ôîë³êóëÿðíèõ òèðîöèò³â ùîäî ðåàë³çàö³¿ åíåðãåòè÷íèõ ïðîöåñ³â, ïðîòå ïðè ïðèéìàíí³ éîãî âåëèêî¿ äîçè åíåðãåòè÷íå çàáåçïå÷åííÿ ïðîöåñ³â ãîðìîíîïîåçó áóëî íàéá³ëüøèì.

Âèñíîâêè. Àíàë³ç êîðåëÿö³éíèõ ïîðòðåò³â ïðîô³ëþ åíåðãåòè÷íî¿ ìîæëèâîñò³ ôîë³êóëÿðíèõ òèðîöèò³â º ³íôîðìàòèâíèì çàñîáîì äîñë³äæåííÿ åíåðãîçàáåçïå÷åííÿ ñïåöèô³÷íî¿ ä³ÿëüíîñò³ ùèòîïîä³áíî¿ çàëîçè çà óìîâ íîðìè òà ïàòîëî㳿. Ïðîÿâàìè çðîñòàííÿ åíåðãåòè÷íîãî ïîòåíö³àëó òèðîöèò³â ïðè ïðèéìàíí³ îðãàí³÷íîãî éîäó º çá³ëüøåí³ ê³ëüêîñò³ åëåìåíò³â åíåðãåòè÷íîãî íàïðÿìó òà â³äíîâëåííÿ òîïîãðàô³÷íîãî çâ’ÿçêó ì³æ óëüòðàñòðóêòóðàìè, ùî çàáåçïå÷óþòü ñïåöèô³÷íó ä³ÿëüí³ñòü òèðîöèòó. Ïðè êîðèãóâàíí³ îðãàí³÷íèì éîäîì ìîðôî-ôóíêö³îíàëüíèõ ðîçëàä³â ùèòîïîä³áíî¿ çàëîçè, çóìîâëåíèõ ïîòåíö³þâàííÿì àë³ìåíòàðíîãî éîäîäåô³öèòó àíòèòèðåî¿äíèì ïðåïàðàòîì, åíåðãîçàáåçïå÷åííÿ ôîë³êóëÿðíèõ òèðîöèò³â çðîñòຠâ³äïîâ³äíî äî äîçè ñïîæèòîãî éîäó. Ïðèéìàííÿ âåëèêî¿ äîçè îðãàí³÷íîãî éîäó íàáëèæຠñòàí óëüòðàñòðóêòóð ïðîô³ëþ åíåðãåòè÷íî¿ ìîæëèâîñò³ ôîë³êóëÿðíèõ òèðîöèò³â äî õàðàêòåðèñòèê ³íòàêòíèõ òâàðèí, ùî âêàçóº íà îïòèì³çóâàííÿ åíåðãåòè÷íîãî íàïðÿìó òèðåî¿äíîãî ãîðìîíîïîåçó.

Ùèòîïîä³áíà çàëîçà, ôîë³êóëÿðíèé òèðîöèò, åíåðãåòè÷í³ ìîæëèâîñò³ ôîë³êóëÿðíèõ òèðîöèò³â, àë³ìåíòàðíèé éîäîäåô³öèò ïîòåíö³éîâàíèé, îðãàí³÷íèé éîä, ìàòåìàòè÷í³ ìåòîäè â ìåäèöèí³, êîðåëÿö³éíèé ïîðòðåò.

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Ðÿáóõà Î.². Ïîòåíö³éîâàíèé àë³ìåíòàðíèé éîäîäåô³öèò: îñîáëèâîñò³ âçàºìîçâ’ÿçê³â ì³æ óëüòðàñòðóêòóðàìè ïðîô³ëþ åíåðãåòè÷íî¿ ìîæëèâîñò³ ôîë³êóëÿðíèõ òèðîöèò³â ïðè êîðèãóâàíí³ ð³çíèìè äîçàìè îðãàí³÷íîãî éîäó. ó㳺íà íàñåëåíèõ ì³ñöü : çá. íàóê. ïð. Ê., 2022. Âèï. 72. Ñ. 68-83.