ó㳺íà íàñåëåíèõ ì³ñöü | ISSN: 2707-0441 eISSN: 2707-045X |
Âèïóñê 72, 2022 - Ñòîð³íêè: 95-100
ÕÀÐÀÊÒÅÐ ÇÌ²Í ÎÊÐÅÌÈÕ Á²Îղ̲×ÍÈÕ ÏÎÊÀÇÍÈʲ  ÓÌÎÂÀÕ ÑÓ̲ÑÍί IJ¯ ÅËÅÊÒÐÎÌÀÃͲÒÍÎÃÎ ÂÈÏÐÎ̲ÍÞÂÀÍÍß 50 Ãö ÒÀ ͲÒÐÎÇÀ̲Ͳ ÍÀ ÎÐÃÀͲÇÌ Ï²ÄÄÎÑ˲ÄÍÈÕ ÒÂÀÐÈÍ
Òîìàøåâñüêà Ë.À.1, Öèöèðóê Â.Ñ.1, Êðàâ÷óí Ò.ª.1, ijäèê Í.Â.1
1 ÄÓ "²ÍÑÒÈÒÓÒ ÃÐÎÌÀÄÑÜÊÎÃÎ ÇÄÎÐÎÂ'ß ²Ì. Î.Ì. ÌÀÐǪªÂÀ ÍÀÌÍÓ"
ÓÄÊ: 614.718:613.648.2
ÀÍÎÒÀÖ²ß:
Ìåòà. Äîñë³äæåííÿ îñîáëèâîñòåé âïëèâó åëåêòðîìàãí³òíîãî âèïðîì³íþâàííÿ òà åíäîãåííèõ í³òðîçàì³í³â (êîìá³íàö³ÿ òåòðàöèêë³íó ç í³òðàòîì íàòð³þ) íà á³îõ³ì³÷í³ ïîêàçíèêè êðîâ³ ï³ääîñë³äíèõ ùóð³â.
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ. Ñïîëó÷åíà ä³ÿ åëåêòðîìàãí³òíîãî âèïðîì³íþâàííÿ òà êîìá³íàö³¿ òåòðàöèêë³íó ç í³òðàòîì íàòð³þ íà á³îõ³ì³÷í³ ïîêàçíèêè êðîâ³.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ.  ðåçóëüòàò³ õðîí³÷íîãî åêñïåðèìåíòó îòðèìàí³ ðåçóëüòàòè ïîêàçàëè, ùî âïëèâ äîñë³äæóâàíèõ ôàêòîð³â íà îðãàí³çì ï³ääîñë³äíèõ òâàðèí ìîæå âèêëèêàòè ïîðóøåííÿ ïîêàçíèê³â ìåòàáîë³÷íèõ ïðîöåñ³â. Òàêà òåíäåíö³ÿ äî äèñáàëàíñó ïîêàçíèê³â ìîæå áóòè ñâîºð³äíèì ³íäèêàòîðîì ìåòàáîë³÷íèõ êîìïåíñàòîðíèõ ïåðåáóäîâ â îðãàí³çì³ ï³ä âïëèâîì åëåêòðîìàãí³òíîãî âèïðîì³íþâàííÿ òà õ³ì³÷íèõ ðå÷îâèí â çàëåæíîñò³ â³ä òåðì³íó 䳿. Íàÿâí³ñòü ÷àñîâî¿ çàëåæíîñò³ ñïîñòåð³ãàëîñÿ ïðè ³çîëüîâàí³é 䳿 ôàêòîð³â, àëå íàéâèðàçí³ø³ çì³íè á³îõ³ì³÷íèõ ïîêàçíèê³â ñïîñòåð³ãàëèñü çà óìîâ ñóì³ñíî¿ ä³¿ ôàêòîð³â, ùî ìîæå ìàòè çíà÷åííÿ äëÿ ïðîãíîçó øê³äëèâîñò³ äîâãîñòðîêîâîãî âïëèâó äîñë³äæóâàíèõ ðå÷îâèí íà ôóíêö³îíàëüíèé ñòàí.
Âèñíîâêè. Á³îõ³ì³÷í³ äîñë³äæåííÿ âèÿâèëè ôóíêö³îíàëüí³ çì³íè ìåòàáîë³÷íèõ ñèñòåì ãîìåîñòàçó. Âñòàíîâëåíî, ùî õàðàêòåð ³ âèðàæåí³ñòü åôåêò³â çàëåæàëè â³ä ä³þ÷èõ ôàêòîð³â òà êîìá³íàö³¿ öèõ ôàêòîð³â. Òàêîæ âàæëèâå çíà÷åííÿ â äàíîìó åêñïåðèìåíò³ â³ä³ãðຠ÷àñ 䳿 ôàêòîðó, îñê³ëüêè íàéâèðàçí³ø³ òà íàéñóòòºâ³ø³ çì³íè äîñë³äæåíèõ ïîêàçíèê³â ïðîÿâèëèñü ëèøå ï³ñëÿ 120 äîáè (4 ì³ñÿö³) âïëèâó.
ÊËÞ×β ÑËÎÂÀ:
Åëåêòðîìàãí³òíå âèïðîì³íþâàííÿ, í³òðàò íàòð³þ, òåòðàöèêë³í, í³òðîçàì³íè, ñïîëó÷åíà ä³ÿ, á³îõ³ì³÷í³ ïîêàçíèêè, çàãàëüíèé á³ëîê, á³ë³ðóá³í, êðåàòèí³í.
˲ÒÅÐÀÒÓÐÀ:
1. Dumansky YuD, Nikitina NG, Bitkin SV. [Development of research in the field of hygiene of electromagnetic environmental factors]. Environment and Health. 2001;2:23-5. Ukrainian.
3. Chernychenko IO. [Carcinogenic environmental factors and their role in the formation of oncological pathology in the population]. In: Experience and prospects of scientific support for the problems of hygienic science and practice. Kyiv; 2011. p. 50-9. Ukrainian.
4. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. Non-ionizing Radiation. Part 2: Radiofrequency Electromagnetic Fields. Lyon: IARC. 2013;102:143-88.
5. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. Chemical Agents and Related Occupations. Lyon: IARC; 2012;100. 576 p.
6. Steward BW, Wild CP (eds.). World Cancer Report 2014. Lyon: IARC; WHO. 630 p.
7. Demetriou CA, Raaschou-Nielsen O, Loft S, et al. Biomarkers of ambient airpollution and lung cancer: asystematic review. Occup.Environ. Med. 2012;69:619-27. doi:
https://doi.org/10.1136/oemed-2011-100566
8. Chennichenko IO, Dumanskyi VYu, Nikitina NG, Serdyuk EA, et al. [Health protection of the population from the effect of the joint action of the magnetic field of industrial frequency – 50 Hz and nitrosamins (on)]. Hygiene of populated places. 2017;67:99-111. Ukrainian. doi:
https://doi.org/10.32402/hygiene2017.67.099
9. OECD. Principles of Good Laboratory Practice. 1996.
10. [General ethical principles of experiments on animals (the document was developed by the working group of the Congress under the leadership of the member-correspondent of the National Academy of Sciences of Ukraine and AMS of Ukraine O.H. Reznikov)]. Endocrinology. 2003;8(1):142-5. Ukrainian.
11. Principles and methods for assessing direct immunotoxicity associated with exposure to chemicals. Geneva: WHO; 1996. 390 p.
12. Prodanchuk MG, Zhminko PG, Zinchenko DV, et al. [Study of the immunotoxic effect of potentially dangerous chemicals under their hygienic regulation: Methodological recommendations]. In: [Collection of regulatory documents on health care]. Kyiv; 2003;8(31):149-68. Ukrainian.
ÄËß ÖÈÒÓÂÀÍÍß:
Òîìàøåâñüêà Ë.À., Öèöèðóê Â.Ñ., Êðàâ÷óí Ò.ª., ijäèê Í.Â. Õàðàêòåð çì³í îêðåìèõ á³îõ³ì³÷íèõ ïîêàçíèê³â â óìîâàõ ñóì³ñíî¿ ä³¿ åëåêòðîìàãí³òíîãî âèïðîì³íþâàííÿ 50 Ãö òà í³òðîçàì³í³â íà îðãàí³çì ï³ääîñë³äíèõ òâàðèí. ó㳺íà íàñåëåíèõ ì³ñöü : çá. íàóê. ïð. Ê., 2022. Âèï. 72. Ñ. 95-100.