| ó㳺íà íàñåëåíèõ ì³ñöü | ISSN: 2707-0441 eISSN: 2707-045X |
Âèïóñê 72, 2022 - Ñòîð³íêè: 11-16
òòªÍ²×ÍÀ ÐÅÃËÀÌÅÍÒÀÖ²ß ²ÊÀÐÈÄÈÍÓ Â ÏβÒв ÐÎÁÎ×ί ÇÎÍÈ
Êóçüì³íîâ Á.Ï.1, Çàçóëÿê Ò.Ñ.1, Òóðê³íà Â.À.1, Êóçüì³íîâ Î.Á.1
1 ËܲÂÑÜÊÈÉ ÍÀÖ²ÎÍÀËÜÍÈÉ ÌÅÄÈ×ÍÈÉ ÓͲÂÅÐÑÈÒÅÒ ²ÌÅͲ ÄÀÍÈËÀ ÃÀËÈÖÜÊÎÃÎ
ÓÄÊ: 613.63.661.168.2
ÀÍÎÒÀÖ²ß:
Ìåòà. Îá´ðóíòóâàííÿ ã³ã³ºí³÷íîãî ðåãëàìåíòó äîïóñòèìîãî âì³ñòó ðåïåëåíòó ³êàðèäèíó ó ïîâ³òð³ ðîáî÷î¿ çîíè.
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ. ³êàðèäèí (1-(1-ìåòèëïðîïîêñèêàðáîí³ë)-2-(2-ã³äðîêñ³åòèë)ï³ïåðèäèí), âèðîáíèöòâà ô³ðìè S.C. Johnson Europlant B.V. (ͳäåðëàíäè). Ìåòîäè äîñë³äæåíü – òîêñèêîëîãî-ã³ã³ºí³÷í³, á³îõ³ì³÷í³, ³ìóíîëîã³÷í³, ô³çèêî-õ³ì³÷í³, ñòàòèñòè÷í³.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Ïðåäñòàâëåí³ ðåçóëüòàòè òîêñèêîëîãî-ã³ã³ºí³÷íèõ äîñë³äæåíü ðåïåëåíòó ³êàðèäèíó íà ëàáîðàòîðíèõ òâàðèíàõ (á³ë³ ìèø³, á³ë³ ùóð³, ìóð÷àêè, êðîë³). Âñòàíîâëåíî, ùî ³êàðèäèí çà ïàðàìåòðàìè ãîñòðî¿ òîêñè÷íîñò³ ïðè îäíîðàçîâîìó âíóòð³øíüîøëóíêîâîìó ââåäåíí³ òà îäíîêðàòíîìó ³íãàëÿö³éíîìó âïëèâîâ³ â³äíîñèòüñÿ äî ïîì³ðíî íåáåçïå÷íèõ ðå÷îâèí (3 êëàñ íåáåçïåêè. Âèäîâà ÷óòëèâ³ñòü òâàðèí äî ðå÷îâèíè â³äñóòíÿ. Ïðè íàíåñåíí³ íà øê³ðó ³êàðèäèí íå âèêëèêຠçàãèáåë³ òâàðèí òà ïðîÿâ³â ì³ñöå-ïîäðàçíþâàëüíî¿ ä³¿. Âïëèâ íà ñëèçîâ³ îáîëîíêè õàðàêòåðèçóºòüñÿ íåçíà÷íîþ ïîøêîäæóþ÷îþ 䳺þ (2 áàëè).  ñóáõðîí³÷íîìó åêñïåðèìåíò³ ïðîÿâëÿº ñëàáêó êóìóëÿòèâíó àêòèâí³ñòü. Õðîí³÷íèé ³íãàëÿö³éíèé âïëèâ ³êàðèäèíó óïðîäîâæ 4 ì³ñÿö³â íå âèêëèêຠçì³í ãåìàòîëîã³÷íèõ ³ á³îõ³ì³÷íèõ ïîêàçíèê³â, ïàòîëî㳿 ðåñï³ðàòîðíèõ øëÿõ³â òà ïàðåíõ³ìàòîçíèõ îðãàí³â. ²êàðèäèí âîëî䳺 ñåíñèá³ë³çóþ÷îþ àêòèâí³ñòþ ³ âèêëèêຠçðîñòàííÿ ê³ëüêîñò³ öèðêóëþþ÷èõ ó êðîâ³ ³ìóííèõ êîìïëåêñ³â. Íå ÷èíèòü òîêñè÷íîãî âïëèâó íà ðåïðîäóêòèâíó ôóíêö³þ. Áåçïå÷íèé â ïëàí³ ðîçâèòêó êàíöåðîãåííîãî åôåêòó. Íà ï³äñòàâ³ âñòàíîâëåíèõ ïàðàìåòð³â òîêñè÷íîñò³ ðîçðàõîâàíî êîåô³ö³ºíò çàïàñó, çàïðîïîíîâàíî ã³ã³ºí³÷íèé ðåãëàìåíò äîïóñòèìîãî âì³ñòó ³êàðèäèíó ó ïîâ³òð³ ðîáî÷î¿ çîíè òà ðîçðîáëåíî ìåòîäèêó âèì³ðþâàííÿ ìàñîâî¿ êîíöåíòðàö³¿ ðå÷îâèíè ó ïîâ³òð³.
Âèñíîâêè. Ãðàíè÷íî äîïóñòèìà êîíöåíòðàö³ÿ ³êàðèäèíó ó ïîâ³òð³ ðîáî÷î¿ çîíè ðåêîìåíäóºòüñÿ íà ð³âí³ 10 ìã/ì3, ïàðè + àåðîçîëü, 3 êëàñ íåáåçïåêè. Ðîçðîáëåíî ãàçîõðîìàòîãðàô³÷íó ìåòîäèêó âèì³ðþâàííÿ ìàñîâî¿ êîíöåíòðàö³¿ ³êàðèäèíó ó ïîâ³òð³.
Îá’ºêò ³ ìåòîäè äîñë³äæåííÿ. ³êàðèäèí (1-(1-ìåòèëïðîïîêñèêàðáîí³ë)-2-(2-ã³äðîêñ³åòèë)ï³ïåðèäèí), âèðîáíèöòâà ô³ðìè S.C. Johnson Europlant B.V. (ͳäåðëàíäè). Ìåòîäè äîñë³äæåíü – òîêñèêîëîãî-ã³ã³ºí³÷í³, á³îõ³ì³÷í³, ³ìóíîëîã³÷í³, ô³çèêî-õ³ì³÷í³, ñòàòèñòè÷í³.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Ïðåäñòàâëåí³ ðåçóëüòàòè òîêñèêîëîãî-ã³ã³ºí³÷íèõ äîñë³äæåíü ðåïåëåíòó ³êàðèäèíó íà ëàáîðàòîðíèõ òâàðèíàõ (á³ë³ ìèø³, á³ë³ ùóð³, ìóð÷àêè, êðîë³). Âñòàíîâëåíî, ùî ³êàðèäèí çà ïàðàìåòðàìè ãîñòðî¿ òîêñè÷íîñò³ ïðè îäíîðàçîâîìó âíóòð³øíüîøëóíêîâîìó ââåäåíí³ òà îäíîêðàòíîìó ³íãàëÿö³éíîìó âïëèâîâ³ â³äíîñèòüñÿ äî ïîì³ðíî íåáåçïå÷íèõ ðå÷îâèí (3 êëàñ íåáåçïåêè. Âèäîâà ÷óòëèâ³ñòü òâàðèí äî ðå÷îâèíè â³äñóòíÿ. Ïðè íàíåñåíí³ íà øê³ðó ³êàðèäèí íå âèêëèêຠçàãèáåë³ òâàðèí òà ïðîÿâ³â ì³ñöå-ïîäðàçíþâàëüíî¿ ä³¿. Âïëèâ íà ñëèçîâ³ îáîëîíêè õàðàêòåðèçóºòüñÿ íåçíà÷íîþ ïîøêîäæóþ÷îþ 䳺þ (2 áàëè).  ñóáõðîí³÷íîìó åêñïåðèìåíò³ ïðîÿâëÿº ñëàáêó êóìóëÿòèâíó àêòèâí³ñòü. Õðîí³÷íèé ³íãàëÿö³éíèé âïëèâ ³êàðèäèíó óïðîäîâæ 4 ì³ñÿö³â íå âèêëèêຠçì³í ãåìàòîëîã³÷íèõ ³ á³îõ³ì³÷íèõ ïîêàçíèê³â, ïàòîëî㳿 ðåñï³ðàòîðíèõ øëÿõ³â òà ïàðåíõ³ìàòîçíèõ îðãàí³â. ²êàðèäèí âîëî䳺 ñåíñèá³ë³çóþ÷îþ àêòèâí³ñòþ ³ âèêëèêຠçðîñòàííÿ ê³ëüêîñò³ öèðêóëþþ÷èõ ó êðîâ³ ³ìóííèõ êîìïëåêñ³â. Íå ÷èíèòü òîêñè÷íîãî âïëèâó íà ðåïðîäóêòèâíó ôóíêö³þ. Áåçïå÷íèé â ïëàí³ ðîçâèòêó êàíöåðîãåííîãî åôåêòó. Íà ï³äñòàâ³ âñòàíîâëåíèõ ïàðàìåòð³â òîêñè÷íîñò³ ðîçðàõîâàíî êîåô³ö³ºíò çàïàñó, çàïðîïîíîâàíî ã³ã³ºí³÷íèé ðåãëàìåíò äîïóñòèìîãî âì³ñòó ³êàðèäèíó ó ïîâ³òð³ ðîáî÷î¿ çîíè òà ðîçðîáëåíî ìåòîäèêó âèì³ðþâàííÿ ìàñîâî¿ êîíöåíòðàö³¿ ðå÷îâèíè ó ïîâ³òð³.
Âèñíîâêè. Ãðàíè÷íî äîïóñòèìà êîíöåíòðàö³ÿ ³êàðèäèíó ó ïîâ³òð³ ðîáî÷î¿ çîíè ðåêîìåíäóºòüñÿ íà ð³âí³ 10 ìã/ì3, ïàðè + àåðîçîëü, 3 êëàñ íåáåçïåêè. Ðîçðîáëåíî ãàçîõðîìàòîãðàô³÷íó ìåòîäèêó âèì³ðþâàííÿ ìàñîâî¿ êîíöåíòðàö³¿ ³êàðèäèíó ó ïîâ³òð³.
ÊËÞ×β ÑËÎÂÀ:
²êàðèäèí, ïàðàìåòðè òîêñè÷íîñò³, ãðàíè÷íî äîïóñòèìà êîíöåíòðàö³ÿ, ïîâ³òðÿ ðîáî÷î¿ çîíè.
˲ÒÅÐÀÒÓÐÀ:
1. U.S. National Library of Medicine [Internet]. Bethesda (MD): National Library of Medicine; 2004 [cited 2022 Jan 15]. PubÑhem. Icaridin. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Icaridin
2. European Convention for the Protection of Vertebrate Animals us ed for Experimental and Other Scientific Purposes: European Communities (EC) – Strasbourg, 18.III.1986. [Internet]. European Treaty Series No. 123. Available from: http://www.conventions.coe.int/treaty/en/treaties/html/123.htm
3. [The procedure for research and experiments on animals by scientific institutions: Order of the Ministry of Education, Science, Youth and Sports of Ukraine dated March 1, 2012 No. 249]. [Ofitsiinyi Visnyk Ukrainy]. 2012;24:82. Ukrainian.
4. U.S. United States Environmental Protection Agency. Pesticides [Internet]. Fact Sheet for Picaridin; 2005 [cited 2022 Jan 15]. Available from: https://www3.epa.gov/pesticides/chem_search/reg_actions/registration/fs_PC-070705_01-May-05.pdf
5. [Methodical guidelines for establishing indicative safe exposure levels of harmful substances in the air of the working area: approved by the Ministry of Health of the USSR from 15.09.85 ¹4000-85]. 1985:34. Ukrainian.
ÄËß ÖÈÒÓÂÀÍÍß:
Êóçüì³íîâ Á.Ï., Çàçóëÿê Ò.Ñ., Òóðê³íà Â.À., Êóçüì³íîâ Î.Á. ó㳺í³÷íà ðåãëàìåíòàö³ÿ ³êàðèäèíó â ïîâ³òð³ ðîáî÷î¿ çîíè. ó㳺íà íàñåëåíèõ ì³ñöü : çá. íàóê. ïð. Ê., 2022. Âèï. 72. Ñ. 11-16.