ó㳺íà íàñåëåíèõ ì³ñöüISSN: 2707-0441 eISSN: 2707-045X
Âèïóñê 72, 2022   -   Ñòîð³íêè: 17-22
ÅÊÑÏÅÐÈÌÅÍÒÀËÜÍÅ ÎÁÃÐÓÍÒÓÂÀÍÍß Ã²Ã²ªÍ²×ÍÎÃÎ ÐÅÃËÀÌÅÍÒÓ ÏÐÅÏÀÐÀÒÓ BARDAP 26 (IJÞ×À ÐÅ×ÎÂÈÍÀ – Á²Ñ(ÄEÖÈË)(2-òÄÐÎÊÑÈÅÒÈË)ÌÅÒÈËÀÇÀͲÓÌ ÏÐÎÏÀÍÎÀÒ) Ó ÏβÒÐßÍÎÌÓ ÑÅÐÅÄÎÂÈÙ²
Òóðê³íà Â.À.1, Êóçüì³íîâ Á.Ï.1, Òðåòüÿêîâà Î.Â.2, Ëóêàñåâè÷ Í.Ô.1, Ùóðêî Ã.Â.1
1 ËܲÂÑÜÊÈÉ ÍÀÖ²ÎÍÀËÜÍÈÉ ÌÅÄÈ×ÍÈÉ ÓͲÂÅÐÑÈÒÅÒ ²ÌÅͲ ÄÀÍÈËÀ ÃÀËÈÖÜÊÎÃÎ
2 ÄÅÐÆÀÂÍŠϲÄÏÐȪÌÑÒÂÎ «ÓÊÐÀ¯ÍÑÜÊÈÉ ÍÀÓÊÎÂÎ-ÄÎÑ˲ÄÍÈÉ ²ÍÑÒÈÒÓÒ ÌÅÄÈÖÈÍÈ ÒÐÀÍÑÏÎÐÒÓ Ì²Í²ÑÒÅÐÑÒÂÀ ÎÕÎÐÎÍÈ ÇÄÎÐÎÂ’ß ÓÊÐÀ¯ÍÈ»

ÓÄÊ: 614.71:546.131
https://doi.org/10.32402/hygiene2022.72.017

ÀÍÎÒÀÖ²ß:
Ìåòà. Íàóêîâå îá´ðóíòóâàííÿ ã³ã³ºí³÷íîãî ðåãëàìåíòó äîïóñòèìîãî âì³ñòó á³îöèäíîãî ïðåïàðàòó «Bardap 26» (àêòèâíà ä³þ÷à ðå÷îâèíà - á³ñ(äeöèë)(2-ã³äðîêñèåòèë ìåòèëàçàí³óì ïðîïàíîàò)ó ïîâ³òðÿíîìó ñåðåäîâèù³
Îá’ºêò ³ ìåòîäè äîñë³äæåíü. Òåõí³÷íèé êîíöåíòðàò ïðåïàðàòó «Bardap 26» ç âì³ñòîì 80% àêòèâíî¿ ä³þ÷î¿ ðå÷îâèíè â åòèëåíãë³êîë³, äèåòèëåíãë³êîë³ òà âîä³. Ìåòîäè äîñë³äæåíü – ñàí³òàðíî-õ³ì³÷í³, òîêñèêîëîã³÷í³, ñòàòèñòè÷í³.
Ðåçóëüòàòè äîñë³äæåííÿ òà ¿õ îáãîâîðåííÿ. Ïðåäñòàâëåí³ ðåçóëüòàòè âèçíà÷åííÿ ìàðêåðíîãî ëåòêîãî êîìïîíåíòó ïðåïàðàòó. Âñòàíîâëåíî, ùî äèíàì³÷íà ð³âíîâàãà âñ³õ ì³ãðóþ÷èõ êîìïîíåíò³â â åêñïîçèö³éí³é êàìåð³ ðåºñòðóºòüñÿ ÷åðåç 24 ãîäèíè. Åòèëåíãë³êîëü (âì³ñò ó ïðåïàðàò³ äî 30%) ïðè 20îÑ íå ì³ãðóº ³ç ïðåïàðàòó âíàñë³äîê âèñîêî¿ òåìïåðàòóðè êèï³ííÿ – 197,3îÑ. Âîäíî÷àñ äîñë³äæåííÿ ì³ãðàö³¿ àì³àêó ïîêàçàëè, ùî ç 1 ã íàâàæêè ïðåïàðàòó «Bardap 26» â ìîäåëüíèõ óìîâàõ âèä³ëÿºòüñÿ 0,016 ìã àì³àêó.
Ïðîâåäåí³ äîñë³äæåííÿ òîêñè÷íèõ åôåêò³â ïðåïàðàòó «Bardap 26» íà îðãàí³çì ññàâö³â ïðè ð³çíèõ øëÿõàõ íàäõîäæåííÿ. Çà êðèòåð³ºì ãîñòðî¿ ïåðîðàëüíî¿ òîêñè÷íîñò³ ïðåïàðàò â³äíîñèòüñÿ äî 3 êëàñó íåáåçïåêè. Âåëè÷èíó ïîêàçíèêà ñåðåäíüîñìåðòåëüíî¿ êîíöåíòðàö³¿ (CL50) â óìîâàõ ³íãàëÿö³éíîãî íàäõîäæåííÿ ïðåïàðàòó íå âäàëîñü äîñÿãíóòè. ³í ïðîÿâëÿº ïîì³ðíó ïîäðàçíþâàëüíó ä³þ íà øê³ðó òà âèðàæåíó ïîäðàçíþâàëüíó ä³þ íà õîð³îàëàíòî¿ñíó îáîëîíêó êóðÿ÷èõ åìáð³îí³â. Âîëî䳺 âèðàæåíèìè êóìóëÿòèâíèìè âëàñòèâîñòÿìè. Ïðåïàðàò íå âèêëèêຠñåíñèá³ë³çàö³¿ îðãàí³çìó.  óìîâàõ õðîí³÷íîãî ³íãàëÿö³éíîãî äîñë³äæåííÿ ïðåïàðàò «Bardap 26» íå âèêëèêàâ êë³í³÷íèõ îçíàê ³íòîêñèêàö³¿ òà çàãèáåë³ òâàðèí â óìîâàõ íàøåãî åêñïåðèìåíòó.
Âèñíîâêè. Âðàõîâóþ÷è âñòàíîâëåí³ ïàðàìåòðè òîêñè÷íîñò³, â³äñóòí³ñòü ïåðåäóìîâ äëÿ óòâîðåííÿ àåðîçîëþ ïðåïàðàòó ÿê ó ïðîöåñ³ âèãîòîâëåííÿ ãîòîâèõ äåç³íôåêö³éíèõ çàñîá³â, òàê ³ ó ïðîöåñ³ ¿õ çàñòîñóâàííÿ, ðåçóëüòàòè äîñë³äæåííÿ õ³ì³÷íîãî ñêëàäó ñóì³ø³ ðå÷îâèí, ùî ì³ãðóþòü ç ïðåïàðàòó «Bardap 26» â ìîäåëüíèõ óìîâàõ, äîö³ëüíî ïðîâîäèòè êîíòðîëü ïîâ³òðÿíîãî ñåðåäîâèùà çà êîíöåíòðàö³ºþ ìàðêåðíî¿ ñïîëóêè - àì³àêîì.

ÊËÞ×β ÑËÎÂÀ:
Ïðåïàðàò «Bardap 26» (á³ñ(äeöèë)(2-ã³äðîêñèåòèë)ìåòèëàçàí³óì ïðîïàíîàò), òîêñèêîëîã³÷í³ äîñë³äæåííÿ, ññàâö³, ã³ã³ºí³÷íèé ðåãëàìåíò.

˲ÒÅÐÀÒÓÐÀ:
1. Serdiuk AM, Polka NS, Koblianska AV, Tsyhulova ÎM, Taran VV, Surmasheva ÎV, et al. [National review of the current situation in the field of biocides management in Ukraine: monograph] [Internet]. Kyiv: Medinform; 2017 [cited 2022 Jul 20]. 270 p. Ukrainian. Available from: http://www.health.gov.ua/docs/NationalReport/National%20Report%20on%20biocides%20in%20Ukraine%202017.pdf
2. [Regulations on hygienic regulation and state registration of dangerous factors: Resolution of the Cabinet of Ministers of Ukraine No. 420 of June 13, 1995] [Internet]. 1995 [cited 2022 Jul 29]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/420-95-ï#Text
3. Assessment Report – Didecylmethylpoly(oxyethyl)ammonium propionate Product-type 8 (Wood Preservative). [Internet]. ECHA [cited 2022 Jul 29]. Available from: https://echa.europa.eu/documents/10162/c2869e58-023f-f788-04a8-5af24df96dad
4. Opinion on the application for approval of the active substance: Didecylmethylpoly(oxyethyl)ammonium propionate Product type: 8. [Internet]. ECHA. [cited 2022 Jul 29]. Available from: https://echa.europa.eu/documents/10162/1c0ba851-8f48-459a-a624-8d25092c9190
5. Registration dossier [Internet]. ECHA. [cited 2022 Jul 29]. Available from: https://echa.europa.eu/registration-dossier/-/registered-dossier/15837
6. [MU 1637-77. Guidelines for the photometric determination of ammonia in the air]. 1977 [cited 2022 Jul 29]. 18 p. Russian.
7. [On the protection of animals from cruel treatment: Law of Ukraine dated February 21, 2006 No. 3447-IV: as of August 8 2021] [Internet]. 2006 [cited 2022 Jul 29]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/3447-15
8. [On the approval of the Procedure for conducting experiments and experiments on animals by scientific institutions: Order of the Ministry of Education, Youth and Sports of Ukraine dated March 1, 2012 No. 249] [Internet]. 2012 [cited 2022 Jul 29]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/z0416-12
9. [MU ¹2163-80. Guidelines for the formulation of studies to substantiate sanitary standards for harmful substances in the air of the working area]. 1980 [cited 2022 Jul 29]. Russian.
10. [MU ¹2102-79. Guidelines for assessing the impact of harmful chemicals on the skin and the rationale for the MPC for skin contamination]. 1979 [cited 2022 Jul 29]. 12 p. Russian.
11. Kuzminov BP, Turkina VA, Bec NG, Chemodurova NY. [Assessment of the irritating effect of chemicals on the chorioallantoic membrane of the chicken embryo: methodological recommendations]. Lviv; 2021. 19 p. Ukrainian.
12. [MR 2121-80. Organization of research on hygienic regulation of industrial allergens in the air of the working area]. 1980 [cited 2022 Jul 29]. Russian.
13. [Methods of conducting studies of the specific activity, safety, quality (effectiveness) of disinfectants and their testing in practice: Order of the Ministry of Health of Ukraine dated September 3, 2020 No. 2024] [Internet]. 2020 [cited 2022 Jul 29]. Ukrainian. Available from: https://moz.gov.ua/article/ministry-mandates/nakaz-moz-ukraini-vid-03092020--2024-pro-zatverdzhennja-metodiv-provedennja-doslidzhen-specifichnoi-aktivnosti-bezpechnosti-jakosti-efektivnosti-dezinfekcijnih-zasobiv-ta-ih-viprobuvannja-na-praktici
14. Makarov VG, Makarova MN. [Physiological, biochemical and biometric indicators of the norm of experimental animals]. SPB: LEMA; 2013. 116 p. Russian.

ÄËß ÖÈÒÓÂÀÍÍß:
Òóðê³íà Â.À., Êóçüì³íîâ Á.Ï., Òðåòüÿêîâà Î.Â., Ëóêàñåâè÷ Í.Ô., Ùóðêî Ã.Â. Åêñïåðèìåíòàëüíå îá´ðóíòóâàííÿ ã³ã³ºí³÷íîãî ðåãëàìåíòó ïðåïàðàòó bardap 26 (ä³þ÷à ðå÷îâèíà – á³ñ(äeöèë)(2-ã³äðîêñèåòèë) ìåòèëàçàí³óì ïðîïàíîàò) ó ïîâ³òðÿíîìó ñåðåäîâèù³. ó㳺íà íàñåëåíèõ ì³ñöü : çá. íàóê. ïð. Ê., 2022. Âèï. 72. Ñ. 17-22.