| Hygiene of populated places | ISSN: 2707-0441 eISSN: 2707-045X |
Issue 69, 2019 - Pages: 88-95
IDENTIFICATION OF NON-CARCINOGENIC RISKS FROM ORAL INTAKE OF PRIORITY CHEMICALS IN THE ORGANISM
I.O. Chernichenko1, V.F. Babii1, O.M. Litvichenko1, O.Ye. Kondratenko1, N.V. Balenko1, D.O. Hlavachek1
1 STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU
ÓÄÊ: 614.7:576.385.5:616-084
SUMMÀRY:
Objective: We studied the state of the pollution of drinking water, foodstuffs (animal and plant origin) with the carcinogenic compounds.
Materials and methods: The prior carcinogens of three classes were selected as indicator substances: polycyclic aromatic hydrocarbons, nitrosamines and heavy metals. Investigations were conducted at the territory of one region – Kyiv and Kyiv oblast.
Results: The results of the presence of prior chemical carcinogens in the main foodstuffs of the population are considered in this article. The total doses of carcinogens, entering into the organism with a food intake, were calculated. The critical organs and systems they affect were established. Ni-trosamines and heavy metals are shown to be the most dangerous by the indicator of non-carcinogenic risk, and liver and gastrointestinal tract are the most sensitive to their impact.
Conclusions: Domestic hygienic standards do not guarantee a safety of domestic products and drinking water for a human. These standards require a revision of the methodological approaches to the assessment of foodstuffs and their unification in accordance with the international norms and standards.
Materials and methods: The prior carcinogens of three classes were selected as indicator substances: polycyclic aromatic hydrocarbons, nitrosamines and heavy metals. Investigations were conducted at the territory of one region – Kyiv and Kyiv oblast.
Results: The results of the presence of prior chemical carcinogens in the main foodstuffs of the population are considered in this article. The total doses of carcinogens, entering into the organism with a food intake, were calculated. The critical organs and systems they affect were established. Ni-trosamines and heavy metals are shown to be the most dangerous by the indicator of non-carcinogenic risk, and liver and gastrointestinal tract are the most sensitive to their impact.
Conclusions: Domestic hygienic standards do not guarantee a safety of domestic products and drinking water for a human. These standards require a revision of the methodological approaches to the assessment of foodstuffs and their unification in accordance with the international norms and standards.
KEYWORDS:
non-carcinogenic risk, chemical pollution, foodstuffs.
REFERENCES:
1. U.S. EPA. Health effects assessment summary tables (HEAST). FY – 1992, Annual. Washington, DC; 1992 : 370 p. URL : https://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=9101POB1.txt
2. Koziarin ².P. Dovkillia ta zdorovia (Environment and Health). 2002 ; 4 : 18-20 (in Ukrainian).
3. Yanysheva N.Ya., Kireeva I.S., Chernichenko I.À. et al. Gigienicheskie problem okhrany okruzhayushchey sredy ot zagryazneniya kantserogenami [Hygienic Problems of the Environmental Protection Against Carcinogen Contamination]. Kiev : Zdorovia ; 1985 : 102 p. (in Russian).
4. Produkty kharchovi. Metody vyznachannia masovoi chastky benz(a)pirenu : DSTU 4689: 2006. [Foodstuffs. Methods for the Determination of Mass Fraction of Benzopyrene: SSTU 4689: 2006] Kyiv : Derzhspozhyvstandart Ukrainy ; 2007 : 23 p. (in Ukrainian).
5. Derzhavni sanitarni pravyla i normy zakhystu prodovolchoi syrovyny ta produktiv kharchuvannia vid zabrudnennia nitroza minamy : DSanPiN 4.4.2.030- 99 [State Sanitary Rules and Norms of the Protection of Food Raw Materials and Foodstuffs against the Pollution with Nitrosamines: DSanRN 4.4.2.030-99]. Kyiv ; 2001 : 21 p. (in Ukrainian).
6. Chernychenko I.O., Sovertkova L.S., Babii V.F., Lytvychenko O.M. and Kondratenko O.Ye. Patent 7170, UA, ÌPC GOI ¹33/18. Sposib vyznachennia kantserohennykh N-nitrozaminiv u vodi [Method for the Determination of Carcinogenic N-nitrosamines in Water]. Application ¹ 20041008117; 07.10.2004; Publ. 15.06.2005; Bull. N6 (in Ukrainian).
7. Obukhov À.I. and Plekhanova I.Î. Atomno-absorbtsionnyi analiz v pochvenno-biologicheskikh issledovaniyakh [Atomic-and-Absorption Analysis in Soil-and-Biological Research]. Moscow ; 1991 : 184 p. (in Russian).
8. Rakhmanin Yu. A., Novikov S. M., Shashina T. A. et al. Rukovodstvo po otsenke riska dlia zdorovia naseleniia pri vozdeistvii khimicheskikh veshchestv, zagriazniayushchikh okruzhaiushchuyu sredu [Guidelines for the Assessment of Public Health Risk from Exposure to Chemicals Con-taminating the Environment]. Moscow : Federalnyi tsentr gossanepidnadzora Minzdrava Rossii ; 2004 : 143 p. (in Russian).
FOR CITATION:
Chernichenko I.O., Babii V.F., Litvichenko O.M., Kondratenko O.Ye., Balenko N.V., Hlavachek D.O. Vyznachennia nekantserohennykh ryzykiv vid peroralnoho nadkhodzhennia priorytetnykh khimichnykh rechovyn v orhanizm [Identification of non-carcinogenic risks from oral intake of priority chemicals in the organism]. In : Hihiiena naselenykh mists : zb. nauk. pr. [Hygiene of Populated Places]. Kyiv ; 2019 ; 69 : 88-95 (in Ukrainian).