Our data characterise priority in the sphere of potable water supply and main problem of wa-ter supply and potable water quality, actual for many regions of Ukraine, including Hulaipolskii re-gion of the Zaporozhskaia area, which population received potable water with deviations on some indicators from hygienic standards. Deterioration qualitative structure of potable water with increas-ing general mineralization during 2008-2012 years in the territory of Hulaipolskii region (in 1,15-12,07) times was established. Tendency to increase of this indicator had been revealed in the Vozne-senskii region (in 14,39-22,65) times; Komsomolskii (in 17,31-19,70) times; Novozlatopolskii (in 9,93-13,45) times; Uspenskii (in 20,72-21,82) times and Malinovskii rural regions (in 14,15-15,78) times. It had been established high level of prevalence stones in the kidneys and urolic system diseas-es, illnesses of blood circulation system, hypertensive illness, ischemic illness of heart in the territory of rural regions: Hulaipolskii, Komsomolskii, Novoslatopolskii, Uspenskii and Malinovskii among adult population, in comparison with annual average level of such diseases in the territory of control Hulaipolskii region (p<0,001). Among an adult population of Hulaipolskii region 1450,55 cases of hypertensive illness, in comparison with annual average level of the same diseases in the Zaporozhskaia area (1387,36 cases on 100 000 population) were revealed. Tendency to increase hypertensive illness in the territory of the most rural regions from 2008 till 2012 year period had been found. There were revealed statistically significant corelative dependences of an average level between sepa-rate components of mineral structure of potable water, such as rigidity, dry rest, general mineralization and prevalence III, XIV classes diseases according to X International Classification of Diseases (R=0,30, p<0,05).