The combined action impact of certain minerals (dry residue, hardness salts, sulphates, chlo-rides, iron) with different content in the water has been investigated. The work used five groups of experimental animals: 1 – control (consuming of standard artesian water) and 4 – experimental (consuming water containing each of selected minerals at the 1, 3, 5 and 10 MAC levels respectively) in 12-month chronic experiment. Functional state of the organism was studied for hematological, bi-ochemical, immunological and other indicators. There was found that the long-term consumption of drinking water, contains a combination of 5-mineral compounds in the range of 1-10 MAC, causes reactions that depend on the experiments` duration and the operating factors level (is a clear rela-tionship "dose-time-effect). The development of changes was noted in 4 and 5 animal groups in the later period of observation (10-12 months). It may be manifestation of the decline in the functional reserves of homeostasis maintenance, which is a moderate protective effect on the potential negative influence factor.
The shift in the body of these groups of animals affect functional changes of metabolic homeo-stasis (markers for protein, carbohydrate, lipid, nucleic acid metabolism), which eventually creates a potential threat to the development of pathological processes in certain organs (heart, liver, kidneys).