The aim of the work was to determine the dynamics of biochemical changes in the blood of animals after lead sulphide nanoparticles and lead nitrate of various sizes exposure in a long-term administration of the substances and thiocetam produced by JSC "Halychpharm".
It was established that thiocetam administration to laboratory animals exposed to lead sul-phide nanoparticles and lead in ionic form, exhibits a pronounced hepatoprotective effect, namely normalizing alanine aminotransferase, and, to a lesser extent, aspartate aminotransferase, as evi-denced by the increase in the De Ritis Ratio (AST/ALT ratio) and reduces dyscirculatory manifestations in the liver parenchyma, as evidenced by morphological studies.