The objective was to determine the antimicrobial activity of the combined use of nano silver and antibiotics. Studied the antimicrobial activity of the composites on the basis of colloidal solution of nano-silver "Silver shield–1000" and group antibiotics aminoglycosides – streptomycin and kana-mycin. The combination of these components showed bactericidal activity, which was several times higher activity of the starting components, which is a manifestation of synergism. The results obtained indicate a promising outlook for further research.