Hygiene of populated placesISSN: 2707-0441 eISSN: 2707-045X
Issue 69, 2019   -   Pages: 96-105
ASSESSMENT OF BIOCIDAL ACTION OF THE COMPOSITES OF SILVER NANOPARTICLES AND ANTIMICROBIALS
O.V. Surmasheva1, L.I. Romanenko1, N.O. Nikonova1, H.I. Korchak1, L.D. Kisterska1, O.B. Loginova1, V.P. Sadokhin1
1 STATE INSTITUTION O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH NAMSU

: 615.33:678.046.3
https://doi.org/10.32402/hygiene2019.69.096

SUMMRY:
A search for new drugs to overcome the resistance of microorganisms and increase of the ef-fectiveness of antimicrobial therapy is an urgent problem in the prevention and treatment of infec-tious-and-inflammatory diseases. Silver, in the form of nanoparticles, allows us to decrease hundreds times the concentration of metal at the conservation of biocidal properties.
The purpose of the work is to evaluate the biocidal action of silver nanoparticles and antimi-crobial agents under their combined use. The antimicrobial activity of composites, based on a con-centrated colloidal solution of silver nanoparticles in glycerol ("Silver Shield-1000") and antimicro-bials of various chemical groups: streptomycin and kanamycin, cefazolin azithromycin and ofloxacin, was studied. We used microbiological methods: suspension test according to the European standards and method of batch dilution in nutrient medium.
The results of the application of nanosilver solution in the combination with antibiotics of the groups of aminoglycosides and cephalosporin indicate the excess of the cumulative effect of the com-ponents in comparison with the isolated effect of their components, a phenomenon of synergism was observed, which allowed to reduce the concentrations of the composite components at the preserva-tion of the bactericidal properties.

KEYWORDS:
antimicrobial action, silver nanoparticles, antimicrobials, combined effect.

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FOR CITATION:
Surmasheva O.V., Romanenko L.I., Nikonova N.O., Korchak H.I., Kisterska L.D., Loginova O.B., Sadokhin V.P. Otsinka biotsydnoi dii kompozytiv z nanochastok sribla ta protymikrobnykh preparativ [Assessment of biocidal action of the composites of silver nanoparticles and antimicrobials]. In : Hihiiena naselenykh mists : zb. nauk. pr. [Hygiene of Populated Places]. Kyiv ; 2019 ; 69 : 96-105 (in Ukrainian).