Hygiene of populated placesISSN: 2707-0441 eISSN: 2707-045X
Issue 72, 2022   -   Pages: 68-83
POTENTIATED ALIMENTARY IODINE DEFICIENCY: FEATURES OF RELATIONSHIPS BETWEEN THE FOLLICULAR THYROCYTES ENERGY CAPABILITY PROFILE ULTRASTRUCTURES WHEN CORRECTED BY DIFFERENT DOSES OF ORGANIC IODINE
O.I. Ryabukha1
1 Lviv Medical Institute

: 616.441-018.7-008.64-085.326]-06:577.337]-076.4
https://doi.org/10.32402/hygiene2022.72.068

SUMMRY:
Objective: to investigate the peculiarities of the interrelationships between the ultrastructures of the energy direction of follicular thyrocytes when consuming organic iodine under the conditions of iodine deficiency potentiation in the diet with the Mercazolil (Thiamazole) antithyroid agent.
Materials and methods. The object of the study were electronograms of the thyroid glands of 40 white non-linear male rats with an initial body weight of 140-160 g, its subject was changes in the follicular thyrocytes morpho-functional state of the energy capability profiles ultrastructures when taking small (minimally effective), moderate and large doses of organic iodine under the conditions of medicinal potentiation of alimentary iodine deficiency with Mercazolil at a dose of 3 mg/kg of body weight. The work was carried out by the Electron microscopy method, Method of semi-quantitative analysis of electronograms, Method on specifying the profiles of special capabilities of hormone-poietic cells, Correlation analysis; the results were interpreted from the standpoint of cytophysiology.
Results. It has been established that with potentiation of alimentary iodine deficiency, the energy supply of thyroid hormone-poiesis is disrupted. The features of correcting the disorders of the hormone-poiesis energy supply with organic iodine were related to the fact of taking iodine and its dose. The increase in the energy potential of follicular thyrocytes under the influence of organic iodine consisted in an increase in the number of mitochondria and ribosomes on their cristae, an increase in the electron density of the mitochondrial matrix, restoration of the topographic connection between the main ultrastructures that ensure the specific activity of the thyrocyte (mitochondria, rough endoplasmic reticulum, Golgi apparatus). Taking even a small amount of organic iodine contributed to the growth of the potential capabilities of follicular thyrocytes to implement energy processes, however, when taking a large dose of it, the energy supply of hormone-poiesis processes was the greatest.
Conclusions. The analysis of correlation portraits of the energy capability profile of follicular thyrocytes is an informative means to study the energy supply of the thyroid glands specific activity under normal and pathological conditions. Manifestations of the increase in the energy potential of thyrocytes when taking organic iodine are the increased number of elements of the energy direction and the restoration of the topographic connection between the ultrastructures that ensure the specific activity of the thyrocyte. When correcting with organic iodine morpho-functional disorders of the thyroid gland caused by the potentiation of alimentary iodine deficiency by an antithyroid drug, the energy supply of follicular thyrocytes increases according to the dose of consumed iodine. Taking a large dose of organic iodine brings the ultrastructural state of the profile of follicular thyrocytes energy capability closer to the characteristics of intact animals, which indicates optimization of the energy direction of thyroid hormone-poiesis.

KEYWORDS:
Thyroid gland, follicular thyrocyte, energy capability of follicular thyrocytes, potentiated alimentary iodine deficiency, organic iodine, mathematical methods in medicine, correlation portrait.

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FOR CITATION:
Ryabukha OI. Potentiated alimentary iodine deficiency: features of relationships between the follicular thyrocytes energy capability profile ultrastructures when corrected by different doses of organic iodine. Hygiene of populated places. 2022;72:68-83. Ukrainian.