| Hygiene of populated places | ISSN: 2707-0441 eISSN: 2707-045X |
Issue 65, 2015 - Pages: 134-141
FEATURES OF TOXIC ACTION OF THE MOST WIDESPREAD ANIONIC SURFACTANTS
O.I. Yalovenko1, O.M. Golichenkov1, O.V. Rayetska1, V.I. Lyshenko1, Z.Iu. Maistrenko1, G.P. Umanets1, O.Iu. Kucherenko1, W.F. Babiy1, O.E. Kondratenko1, M.V. Pimushyna1, Ye.I. Vinarska1, L.Ye. Hryhorenko1, N.B. Moldavska1, L.A. Tomashevskaya1, N.V. Didyk1
1 STATE INSTITUTION «O.M. MARZIEIEV INSTITUTE OF HYGIENE AND MEDICAL ECOLOGY» NAMSU
SUMMÀRY:
The purpose of our work: to define to the feature of biological action of anionic surfactants as ingredients of cosmetic facilities
Materials and methods of researches. 3 anionic surfactants are explored in work: Sodium Lauryl Sulfate, Sodium Laureth Sulfate, Disodium Laureth Sulfosuccinate. Researches were conduct-ed by methods: in vitro estimations of cytotoxic and raising of chronic experiment on guinea-pigs with estimation of hematological, immunological and biochemical parameters of blood.
Results of researches and conclusions. It is experimentally proved in work, that listed above anionic surfactant have by cytotoxic and skin absorption properties. It is set that oppression of im-munity of organism is a basic tendency in metabolic violations of immune status at transdermal influ-ence of all these surfactants. At action of Sodium Lauryl Sulfate and Sodium Laureth Sulfate on a background stable suppression of separate links of the immune system sensitization action is ob-served, and Disodium Laureth Sulfosuccinate does not possess sensitization action is observed.
Materials and methods of researches. 3 anionic surfactants are explored in work: Sodium Lauryl Sulfate, Sodium Laureth Sulfate, Disodium Laureth Sulfosuccinate. Researches were conduct-ed by methods: in vitro estimations of cytotoxic and raising of chronic experiment on guinea-pigs with estimation of hematological, immunological and biochemical parameters of blood.
Results of researches and conclusions. It is experimentally proved in work, that listed above anionic surfactant have by cytotoxic and skin absorption properties. It is set that oppression of im-munity of organism is a basic tendency in metabolic violations of immune status at transdermal influ-ence of all these surfactants. At action of Sodium Lauryl Sulfate and Sodium Laureth Sulfate on a background stable suppression of separate links of the immune system sensitization action is ob-served, and Disodium Laureth Sulfosuccinate does not possess sensitization action is observed.