| Hygiene of populated places | ISSN: 2707-0441 eISSN: 2707-045X |
Issue 72, 2022 - Pages: 95-100
THE CHARACTER OF CHANGES IN INDIVIDUAL BIOCHEMICAL INDICATORS UNDER THE CONDITIONS OF THE COMBINED EFFECT OF ELECTROMAGNETIC FIELD 50 Hz AND NITROSAMINE ON THE ORGANISMS OF RESEARCH ANIMALS
L.A. Tomashevskaya1, V.S. Tsótsóruk1, T.E. Kravchun1, N.V. Diduk1
1 STATE INSTITUTION “O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH” NAMSU
ÓÄÊ: 614.718:613.648.2
SUMMÀRY:
Objective. Advancement of the effects of electromagnetic radiation and endogenous nitrosamines (a combination of tetracycline and sodium nitrate) on the biochemical parameters of the blood of experimental rats.
Materials and methods. Combined effect of electromagnetic radiation and combination of tetracycline with sodium nitrate on the biochemical parameters.
Results. As a result of the chronic experiment, the obtained results showed that the influence of the studied factors on the body of experimental animals can cause a violation of the indicators of metabolic processes. Such a tendency to imbalance indicators can be a kind of indicator of metabolic compensatory changes in the body under the influence of electromagnetic radiation and chemicals, depending on the duration of action. The presence of time dependence was observed with the isolated effect of the factors, but the most pronounced changes in biochemical indicators were observed under the conditions of the combined effect of the factors, which may be important for the prediction of the harmfulness of the long-term effects of the studied substances on the functional state.
Conclusions. Biochemical studies revealed functional changes in the metabolic systems of homeostasis. It was established that the nature and severity of the effects depended on the active factors and the combination of these factors. Also, the time of the factor's action plays an important role in this experiment, since the most pronounced and significant changes in the studied parameters were manifested only after 120 days (4 months) of exposure.
Materials and methods. Combined effect of electromagnetic radiation and combination of tetracycline with sodium nitrate on the biochemical parameters.
Results. As a result of the chronic experiment, the obtained results showed that the influence of the studied factors on the body of experimental animals can cause a violation of the indicators of metabolic processes. Such a tendency to imbalance indicators can be a kind of indicator of metabolic compensatory changes in the body under the influence of electromagnetic radiation and chemicals, depending on the duration of action. The presence of time dependence was observed with the isolated effect of the factors, but the most pronounced changes in biochemical indicators were observed under the conditions of the combined effect of the factors, which may be important for the prediction of the harmfulness of the long-term effects of the studied substances on the functional state.
Conclusions. Biochemical studies revealed functional changes in the metabolic systems of homeostasis. It was established that the nature and severity of the effects depended on the active factors and the combination of these factors. Also, the time of the factor's action plays an important role in this experiment, since the most pronounced and significant changes in the studied parameters were manifested only after 120 days (4 months) of exposure.
KEYWORDS:
Electromagnetic radiation, sodium nitrate, tetracycline, nitrosamines, combined action, biochemical indicators, total protein, bilirubin, creatinine.
REFERENCES:
1. Dumansky YuD, Nikitina NG, Bitkin SV. [Development of research in the field of hygiene of electromagnetic environmental factors]. Environment and Health. 2001;2:23-5. Ukrainian.
2. Grigoriev OA. [From electromagnetic smog to electromagnetic chaos. To assess the dangers of mobile communication for the health of the population]. Medical radiology and radiation safety. 2018;3:28-33. Russian. doi: https://doi.org/10.12737/article_5b168a752d92b1.01176625
3. Chernychenko IO. [Carcinogenic environmental factors and their role in the formation of oncological pathology in the population]. In: Experience and prospects of scientific support for the problems of hygienic science and practice. Kyiv; 2011. p. 50-9. Ukrainian.
4. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. Non-ionizing Radiation. Part 2: Radiofrequency Electromagnetic Fields. Lyon: IARC. 2013;102:143-88.
5. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. Chemical Agents and Related Occupations. Lyon: IARC; 2012;100. 576 p.
6. Steward BW, Wild CP (eds.). World Cancer Report 2014. Lyon: IARC; WHO. 630 p.
7. Demetriou CA, Raaschou-Nielsen O, Loft S, et al. Biomarkers of ambient airpollution and lung cancer: asystematic review. Occup.Environ. Med. 2012;69:619-27. doi: https://doi.org/10.1136/oemed-2011-100566
8. Chennichenko IO, Dumanskyi VYu, Nikitina NG, Serdyuk EA, et al. [Health protection of the population from the effect of the joint action of the magnetic field of industrial frequency – 50 Hz and nitrosamins (on)]. Hygiene of populated places. 2017;67:99-111. Ukrainian. doi: https://doi.org/10.32402/hygiene2017.67.099
9. OECD. Principles of Good Laboratory Practice. 1996.
10. [General ethical principles of experiments on animals (the document was developed by the working group of the Congress under the leadership of the member-correspondent of the National Academy of Sciences of Ukraine and AMS of Ukraine O.H. Reznikov)]. Endocrinology. 2003;8(1):142-5. Ukrainian.
11. Principles and methods for assessing direct immunotoxicity associated with exposure to chemicals. Geneva: WHO; 1996. 390 p.
12. Prodanchuk MG, Zhminko PG, Zinchenko DV, et al. [Study of the immunotoxic effect of potentially dangerous chemicals under their hygienic regulation: Methodological recommendations]. In: [Collection of regulatory documents on health care]. Kyiv; 2003;8(31):149-68. Ukrainian.
FOR CITATION:
Tomashevskaya LA, Tsótsóruk VS, Kravchun TE, Diduk NV. The character of changes in individual biochemical indicators under the conditions of the combined effect of electromagnetic field 50 Hz and nitrosamine on the organisms of research animals. Hygiene of populated places. 2022;72:95-100. Ukrainian.