| Hygiene of populated places | ISSN: 2707-0441 eISSN: 2707-045X |
Issue 72, 2022 - Pages: 11-16
HYGIENIC REGULATION OF ICARIDIN IN THE AIR OF THE WORKING AREA
B.P. Kuzminov1, T.S. Zazulyak1, V.A. Turkinà1, O.B. Kuzminov1
1 DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
ÓÄÊ: 613.63.661.168.2
SUMMÀRY:
Objective. Substantiation of the hygienic regulations for the permissible content of the repellent icaridin in the air of the working area.
Materials and methods. Icaridin (1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine), manufactured by S.C. Johnson Europlant B.V. (The Netherlands). Research methods are the following: toxicological-hygienic, biochemical, immunological, physico-chemical, statistical.
Results. The results of toxicological and hygienic studies of the repellent icaridin on laboratory animals (white mice, white rats, guinea pigs, rabbits) are presented. It has been established that icaridin, in terms of acute toxicity with a single intragastric administration and a single inhalation exposure, belongs to moderately hazardous substances (hazard class 3). Species sensitivity of animals to the substance is absent. When applied to the skin, icaridin does not cause death of animals and manifestations of an irritant effect. The impact on the mucous membranes is characterized by a slight (minor) damaging effect (2 points). In the subchronic experiment, it shows a weak cumulative activity. Chronic inhalation effect of icaridine for 4 months does not cause changes in hematological and biochemical parameters, pathology of the respiratory tract and parenchymal organs. Icaridin has sensitizing activity and causes an increase in the number of immune complexes circulating in the blood. It does not have a toxic effect on reproductive function and is safe in terms of the development of a carcinogenic effect. Based on the established toxicity parameters, a safety factor was calculated, a hygienic regulation for the permissible content of icaridin in the air of the working area was proposed, and a method for measuring the mass concentration of a substance in the air was developed.
Conclusions. The maximum allowable concentration of icaridin in the air of the working area is recommended at the level of 10 mg/m3, vapors + aerosol, hazard class 3. A gas chromatographic technique for measuring the mass concentration of icaridin in air has been developed.
Materials and methods. Icaridin (1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine), manufactured by S.C. Johnson Europlant B.V. (The Netherlands). Research methods are the following: toxicological-hygienic, biochemical, immunological, physico-chemical, statistical.
Results. The results of toxicological and hygienic studies of the repellent icaridin on laboratory animals (white mice, white rats, guinea pigs, rabbits) are presented. It has been established that icaridin, in terms of acute toxicity with a single intragastric administration and a single inhalation exposure, belongs to moderately hazardous substances (hazard class 3). Species sensitivity of animals to the substance is absent. When applied to the skin, icaridin does not cause death of animals and manifestations of an irritant effect. The impact on the mucous membranes is characterized by a slight (minor) damaging effect (2 points). In the subchronic experiment, it shows a weak cumulative activity. Chronic inhalation effect of icaridine for 4 months does not cause changes in hematological and biochemical parameters, pathology of the respiratory tract and parenchymal organs. Icaridin has sensitizing activity and causes an increase in the number of immune complexes circulating in the blood. It does not have a toxic effect on reproductive function and is safe in terms of the development of a carcinogenic effect. Based on the established toxicity parameters, a safety factor was calculated, a hygienic regulation for the permissible content of icaridin in the air of the working area was proposed, and a method for measuring the mass concentration of a substance in the air was developed.
Conclusions. The maximum allowable concentration of icaridin in the air of the working area is recommended at the level of 10 mg/m3, vapors + aerosol, hazard class 3. A gas chromatographic technique for measuring the mass concentration of icaridin in air has been developed.
KEYWORDS:
Icaridin, toxicity parameters, maximum allowable concentration, control of the working area.
REFERENCES:
1. U.S. National Library of Medicine [Internet]. Bethesda (MD): National Library of Medicine; 2004 [cited 2022 Jan 15]. PubÑhem. Icaridin. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Icaridin
2. European Convention for the Protection of Vertebrate Animals us ed for Experimental and Other Scientific Purposes: European Communities (EC) – Strasbourg, 18.III.1986. [Internet]. European Treaty Series No. 123. Available from: http://www.conventions.coe.int/treaty/en/treaties/html/123.htm
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4. U.S. United States Environmental Protection Agency. Pesticides [Internet]. Fact Sheet for Picaridin; 2005 [cited 2022 Jan 15]. Available from: https://www3.epa.gov/pesticides/chem_search/reg_actions/registration/fs_PC-070705_01-May-05.pdf
5. [Methodical guidelines for establishing indicative safe exposure levels of harmful substances in the air of the working area: approved by the Ministry of Health of the USSR from 15.09.85 ¹4000-85]. 1985:34. Ukrainian.
FOR CITATION:
Kuzminov BP, Zazulyak TS, Turkinà VA, Kuzminov OB. Hygienic regulation of icaridin in the air of the working area. Hygiene of populated places. 2022;72:11-16. Ukrainian.