The experimental studies of acute oral toxicity and skin irritation of laboratory animals have shown that tank mixes Actellik 500 EC+Topaz 100 EC (¹1) and Actellic 500 EC+Chorus 75 WG (¹2) are low-toxic compounds and pertain to IV class of hazard; according irritation of the eyes mu-cous membranes tank mix ¹1 – pertain to the II class of hazard, mix ¹2 – to the III class according to the hygienic classification of pesticides. The results of the toxicometry parameters study showed that tank mixes do not exhibit a more pronounced toxic effect in comparison with the individual com-ponents of the mixtures.