Hygiene of populated placesISSN: 2707-0441 eISSN: 2707-045X
Issue 65, 2015   -   Pages: 59-66
HYGIENIC SUBSTANTIATION OF A NEW CLASS TRIAZOLOPYRIMIDINES FUNGICIDE AMETOCTRADIN MAXIMUM ALLOWABLE CONCENTRATION IN THE WATER OF PONDS
S. Bilous1
1 INSTITUTE OF HYGIENE AND ECOLOGY OF THE BOGOMOLETS NATIONAL MEDICAL UNIVERSITY

ÓÄÊ: 613:632.952:628.113

SUMMÀRY:
Today one of the most promising representatives of fungicides is ametoctradin pertaining to the triazolopyrimidines class as highly effective at low application rates. Hygienic standards and reg-ulations are not approved for this substance in Ukraine. Taking into account the abovementioned, we have conducted experimental studies to substantiate the standard of it in the water using physical-chemical, organoleptic, photometric, chromatographic, and statistical analysis methods.
As a result of experimental studies threshold concentrations of ametoctradin were established by the influence: on organoleptic properties of water at the level of 0.05 mg/dm3, on the general sani-tary regimen of pond – 0.005 mg/dm3 and on sanitary-toxicological index of hazard – 0.4 mg/dm3.
The findings allowed us to establish a limiting index of hazard (general sanitary) and to sub-stantiate scientifically evidence-based MAC of ametoctradin in the water at the level of 0.005 mg/dm3. If the ametoctradin content in the water will be at MAC level and average daily water consumption is 3 dm3 the possible intake of active ingredient will be 0,015 mg/day, which is 0.13% of the acceptable daily intake of substance for human body, calculated on the basis of the established acceptable daily intake, confirming the safety of substantiated standard.